INTERLEUKIN-4 STIMULATES COLLAGEN GENE-EXPRESSION IN HUMAN FIBROBLAST MONOLAYER-CULTURES - POTENTIAL ROLE IN FIBROSIS

被引：99

作者：

GILLERY, P

FERTIN, C

NICOLAS, JF

CHASTANG, F

KALIS, B

BANCHEREAU, J

MAQUART, FX

机构：

[1] FAC MED REIMS,RECH BIOMED & DERMATOL LAB,F-51095 REIMS,FRANCE

[2] HOP EDOUARD HERRIOT,INSERM,U346,F-69437 LYONS 03,FRANCE

[3] SCHERING PLOUGH CORP,RECH IMMUNOL LAB,F-69572 DARDILLY,FRANCE

来源：

FEBS LETTERS | 1992年 / 302卷 / 03期

关键词：

INTERLEUKIN-4; FIBROBLAST; COLLAGEN SYNTHESIS; COLLAGEN GENE EXPRESSION; FIBROSIS;

D O I：

10.1016/0014-5793(92)80448-P

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A role for the cytokines produced by tissue-infiltrated inflammatory cells (mainly T-lymphocytes and mast cells) in the pathophysiology of fibrosis has been suggested by several groups. Among the products of these cells, interleukin-4 (IL-4) might be one of the factors involved in the initiation of the fibrotic process. We studied the effects of recombinant human IL-4 on human fibroblast monolayer cultures. IL-4 (10 and 100 U/ml) induced a dose-dependent increase of collagen production. Non-collagen protein synthesis was not significantly altered. A concomitant increase of pro-alpha-1(I) collagen mRNAs was observed, showing that IL-4 acts at a pre-translational level.

引用

页码：231 / 234

页数：4

共 25 条

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