N-(QUINUCLIDIN-3-YL)-1,8-NAPHTHALIMIDES WITH 5-HT(3) RECEPTOR ANTAGONIST AND 5-HT(4) RECEPTOR AGONIST PROPERTIES

被引：22

作者：

CLARK, RD

WEINHARDT, KK

BERGER, J

LEE, CH

LEUNG, E

WONG, EHF

SMITH, WL

EGLEN, RM

机构：

[1] Syntex Research, Palo Alto

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(00)80352-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The enantiomers of N-(quinuclidin-3-yl)-4-amino-3-chloro-1,8-naphthalimide (3) were examined for interactions at 5-HT3 and 5-HT4 receptors. (R)-3 was found to be a potent 5-HT3 receptor antagonist while (S)-3 was found to be a 5-HT4 receptor agonist with reduced 5-HT3 receptor affinity.

引用

页码：1375 / 1378

页数：4