TAU-PROTEIN CONCENTRATIONS IN CEREBROSPINAL-FLUID OF PATIENTS WITH DEMENTIA OF THE ALZHEIMER-TYPE

被引：81

作者：

TATO, RE

FRANK, A

HERNANZ, A

机构：

[1] HOSP LA PAZ,SERV BIOQUIM,E-28046 MADRID,SPAIN

[2] HOSP LA PAZ,NEUROL SERV,MADRID,SPAIN

来源：

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 1995年 / 59卷 / 03期

关键词：

CEREBROSPINAL FLUID; TAU PROTEIN; MSE TEST; AIZHEIMERS DISEASE; MULTIINFARCT DEMENTIA;

D O I：

10.1136/jnnp.59.3.280

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Tau protein concentrations were measured in the CSF of 23 patients with dementia of the Alzheimer type (DAT), 36 patients with multi-infarct dementia (MID), and 23 control subjects. Tau protein concentrations were significantly higher in patients with DAT than in controls (P < 0.001) and patients with IMID (P < 0.001). A significantly positive correlation between CSF tau protein and glucose concentrations (r = 0.79, P < 0.001) and evolution of disease (r = 0.47, P < 0.05), and a negative correlation with Folstein's mental state examination test (r = -0.73, P < 0.001) were found in patients with DAT.

引用

页码：280 / 283

页数：4

共 25 条

[11] DIAGNOSIS OF ALZHEIMERS-DISEASE
KHACHATURIAN, ZS
[J]. ARCHIVES OF NEUROLOGY, 1985, 42 (11) : 1097 - 1104
[12] BRAIN LEVELS OF MICROTUBULE-ASSOCIATED PROTEIN-TAU ARE ELEVATED IN ALZHEIMERS-DISEASE - A RADIOIMMUNO-SLOT-BLOT ASSAY FOR NANOGRAMS OF THE PROTEIN
KHATOON, S
GRUNDKEIQBAL, I
IQBAL, K
[J]. JOURNAL OF NEUROCHEMISTRY, 1992, 59 (02) : 750 - 753
[13] RELATIONSHIP OF INTERLEUKIN-1-BETA AND BETA(2)-MICROGLOBULIN WITH NEUROPEPTIDES IN CEREBROSPINAL-FLUID OF PATIENTS WITH DEMENTIA OF THE ALZHEIMER-TYPE
MARTINEZ, M
FRANK, A
HERNANZ, A
[J]. JOURNAL OF NEUROIMMUNOLOGY, 1993, 48 (02) : 235 - 240
[14] MICROTUBULE-ASSOCIATED PROTEINS - THEIR POTENTIAL ROLE IN DETERMINING NEURONAL MORPHOLOGY
MATUS, A
[J]. ANNUAL REVIEW OF NEUROSCIENCE, 1988, 11 : 29 - 44
[15] MCKEEL DW, 1993, ALZ DIS ASSOC DIS, V7, P129
[16] MCKHANN G, 1984, NEUROLOGY, V34, P939, DOI 10.1212/WNL.34.7.939
[17] AFFINITY PURIFICATION OF HUMAN TAU-PROTEINS AND THE CONSTRUCTION OF A SENSITIVE SANDWICH ENZYME-LINKED-IMMUNOSORBENT-ASSAY FOR HUMAN TAU-DETECTION
MERCKEN, M
VANDERMEEREN, M
LUBKE, U
SIX, J
BOONS, J
VANMECHELEN, E
VANDEVOORDE, A
GHEUENS, J
[J]. JOURNAL OF NEUROCHEMISTRY, 1992, 58 (02) : 548 - 553
[18] MORRIS JC, 1992, NEUROLOGY, V41, P469
[19] SOMATOSTATIN IMMUNOREACTIVITY IN NEURITIC PLAQUES OF ALZHEIMERS PATIENTS
MORRISON, JH
ROGERS, J
SCHERR, S
BENOIT, R
BLOOM, FE
[J]. NATURE, 1985, 314 (6006) : 90 - 92
[20] MUKAETOVALADINS.EB, 1993, AM J PATHOL, V143, P565

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