TAU-PROTEIN CONCENTRATIONS IN CEREBROSPINAL-FLUID OF PATIENTS WITH DEMENTIA OF THE ALZHEIMER-TYPE

被引:81
作者
TATO, RE
FRANK, A
HERNANZ, A
机构
[1] HOSP LA PAZ,SERV BIOQUIM,E-28046 MADRID,SPAIN
[2] HOSP LA PAZ,NEUROL SERV,MADRID,SPAIN
关键词
CEREBROSPINAL FLUID; TAU PROTEIN; MSE TEST; AIZHEIMERS DISEASE; MULTIINFARCT DEMENTIA;
D O I
10.1136/jnnp.59.3.280
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Tau protein concentrations were measured in the CSF of 23 patients with dementia of the Alzheimer type (DAT), 36 patients with multi-infarct dementia (MID), and 23 control subjects. Tau protein concentrations were significantly higher in patients with DAT than in controls (P < 0.001) and patients with IMID (P < 0.001). A significantly positive correlation between CSF tau protein and glucose concentrations (r = 0.79, P < 0.001) and evolution of disease (r = 0.47, P < 0.05), and a negative correlation with Folstein's mental state examination test (r = -0.73, P < 0.001) were found in patients with DAT.
引用
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页码:280 / 283
页数:4
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