INTERACTION AND REACTIVITY OF CARCINOGENIC N-ACETYL-N-(ACYLOXY)-2-AMINOFLUORENE WITH DEOXYGUANOSINE - AN INTRAMOLECULAR APPROACH

被引：8

作者：

DEFRANCQ, E ^{[1
]}

PELLOUX, N ^{[1
]}

LETERME, A ^{[1
]}

LHOMME, MF ^{[1
]}

LHOMME, J ^{[1
]}

机构：

[1] UNIV GRENOBLE 1,LEDSS,CNRS,WRA 332,BP 53X,F-38041 GRENOBLE,FRANCE

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1991年 / 56卷 / 16期

关键词：

D O I：

10.1021/jo00016a001

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Solvolysis of 3 in water-acetone mixtures yields the ''adduct'' 4 (65% in water) with product and rate data consistent with the hypothesis that hydrophobic guanine-fluorene stacking, similar to that which occurs when the carcinogenic aminofluorene metabolite is intercalated in DNA, is responsible for selective binding of the carcinogen at the C-8 guanine center.

引用

页码：4817 / 4819

页数：3