NEURON GLIA INTERACTIONS - EFFECT OF SEROTONIN ON THE ASTROGLIAL EXPRESSION OF GFAP AND OF ITS ENCODING MESSAGE

被引：55

作者：

LEPRINCE, G

COPIN, MC

HARDIN, H

BELIN, MF

BOUILLOUX, JP

TARDY, M

机构：

[1] HOP HENRI MONDOR,INSERM,U282,F-94010 CRETEIL,FRANCE

[2] FAC MED ALEXIS CARREL,ANAT PATHOL LAB,INSERM,U171,F-69372 LYONS 2,FRANCE

来源：

DEVELOPMENTAL BRAIN RESEARCH | 1990年 / 51卷 / 02期

关键词：

Astrocyte primary culture; Glial fibrillary acidic protein; Rat; Serotonin;

D O I：

10.1016/0165-3806(90)90290-F

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The trophic effect of serotonin on the glial fibrillary acidic protein (GFAP) expression was investigated in rat brainstem astrocytes in primary culture. GFAP immunolabelling decreased and gliofilaments appeared localized in the cytoplasm periphery. GFAP protein level decreased in parallel with a decrease in its encoding message. Serotonin may act as an inhibitor of GFAP expression either on the transcription or on the stability of the GFAP-mRNA. © 1990.

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页码：295 / 298

页数：4

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