SOLUBLE INTERLEUKIN-2 RECEPTORS AND AUTOANTIBODIES IN THE SERUM OF HEALTHY ELDERLY INDIVIDUALS

被引：31

作者：

MANOUSSAKIS, MN

STAVROPOULOS, ED

GERMANIDIS, GS

PAPASTERIADES, CA

GARALEA, KL

DONTAS, AS

MOUTSOPOULOS, HM

机构：

[1] Laboratory of Clinical Immunology, Department of Internal Medicine, Medical School, University of Ioannina, Ioannina

[2] Department of Immunology and Histocompatibility, Evangelismos Hospital, Athens

[3] Athens Home for the Aged, Athens

来源：

AUTOIMMUNITY | 1990年 / 7卷 / 2-3期

关键词：

Autoantibodies; Elderly; HLA antigens; Soluble interleukin-2 receptors;

D O I：

10.3109/08916939008993385

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recently, we reported an increased incidence of various autoantibodies in a healthy elderly population (Group A, 64 subjects). Presently we examined whether there is variability in the expression of the age-associated immunological aberrations between different geriatric populations by extending our observations in another healthy elderly population (Group B, 119 subjects). We also determined the serum levels of soluble IL-2 receptors (slL-2R) attempting to define the activation status of the immune system during senescence. Compared to non-elderly controls, healthy elderly individuals exhibited a significantly higher incidence of autoantibodies as well as significantly higher levels of sIL-2R in serum (p < 0.001). the latter possibly suggesting the occurrence of lymphocytic activation during the ageing process. The overall prevalence of autoantibodies was statistically associated with the presence of raised sIL-2R levels in serum (p < 0.005). These aberrant immunological phenomena were more frequent among the elderly of group A, compared to group B (p< 0.005). In contrast to the uniform expression of various autoantibodies previously observed in group A, the autoantibody profile of group B consisted mainly of rheumatoid factor and antibodies to single-stranded DNA. Finally, no association could be demonstrated between the presence of autoantibodies and HLA antigens in 42 elderly studied. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：129 / 137

页数：9

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