HISTOPATHOLOGICAL EVIDENCE OF PROTECTIVE ACTION OF GARLIC AGAINST COLLAGEN AND ARACHIDONIC-ACID TOXICITY IN RABBITS

被引：8

作者：

ALNAQEEB, MA

ALI, M

THOMSON, M

KHATER, SH

GOMES, SA

ALHASSAN, JM

机构：

[1] KUWAIT UNIV,FAC SCI,DEPT ZOOL,POB 5969,13060 SAFAT,KUWAIT

[2] KUWAIT UNIV,FAC SCI,DEPT BIOCHEM,13060 SAFAT,KUWAIT

来源：

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 1992年 / 46卷 / 04期

关键词：

D O I：

10.1016/0952-3278(92)90040-P

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Soluble rat tail tendon collagen produced respiratory distress, agitation, convulsions and finally death in rabbits when infused intravenously (i.v.) in lethal doses. Similar observations were noted when a lethal dose of arachidonic acid (unsaturated essential fatty acid) was infused. These agents caused thrombocytopenia, indicative of in vivo platelet aggregation, hypotension and increased levels of thromboxane (TX) B2 (a stable metabolite of TXA2) in the plasma. Histopathological examination of lung, heart and liver tissue indicated that the lungs and livers of treated animals were adversely affected, while heart tissues appeared to be normal. Histopathological examination of lung and liver tissues of animals pretreated with garlic, then treated with a lethal dose of collagen or arachidonic acid showed a significant reduction in the damage observed compared to animals not pretreated with garlic.

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收藏

页码：301 / 306

页数：6

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