INHIBITORY EFFECT OF CONJUGATED DIENOIC DERIVATIVES OF LINOLEIC-ACID AND BETA-CAROTENE ON THE INVITRO GROWTH OF HUMAN CANCER-CELLS

被引：182

作者：

SHULTZ, TD ^{[1
]}

CHEW, BP ^{[1
]}

SEAMAN, WR ^{[1
]}

LUEDECKE, LO ^{[1
]}

机构：

[1] WASHINGTON STATE UNIV, DEPT ANIM SCI, PULLMAN, WA 99164 USA

来源：

CANCER LETTERS | 1992年 / 63卷 / 02期

关键词：

CONJUGATED LINOLEIC ACID (CLA); BETA-CAROTENE; MELANOMA; COLORECTAL; BREAST; CANCER CELLS;

D O I：

10.1016/0304-3835(92)90062-Z

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The effects of physiologic concentrations of conjugated linoleic acid (CLA) and beta-carotene were assessed on human (M21-HPB, malignant melanoma; HT-29, colorectal; MCF-7, breast) cancer cells. The incubation of cancer cells with CLA showed significant reductions in proliferation (18-100%) compared to control cultures. M21-HPB and MCF-7 cell mortality was dose- and time-dependent. Beta-carotene was inhibitory to breast cells only. MCF-7 cells supplemented with CLA incorporated significantly less [H-3]leucine (45%), [H-3]uridine (63%) and [H-3]thymidine (46%) than control cultures. M21-HPB and HT-29 cells supplemented with CLA incorporated less [H-3]-leucine (25-30%). These in vitro results suggest that CLA and beta-carotene may be cytotoxic to human cancer cells in vivo.

引用

页码：125 / 133

页数：9

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