ALCOHOL AND COLORECTAL-CANCER - A CASE-CONTROL STUDY FROM NORTHERN ITALY

被引：20

作者：

BARRA, S

NEGRI, E

FRANCESCHI, S

GUARNERI, S

LAVECCHIA, C

机构：

来源：

CANCER CAUSES & CONTROL | 1992年 / 3卷 / 02期

关键词：

ALCOHOL CONSUMPTION; COLON CANCER; ITALY; RECTAL CANCER;

D O I：

10.1007/BF00051655

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The role of alcohol consumption in the etiology of colorectal cancer has been investigated in a case-control study conducted from 1985 to 1990 in the northern part of Italy, on 889 cases of colon cancer, 581 cases of rectal cancer, and 2,475 controls admitted to hospital for acute, non-neoplastic, nondigestive disorders. After allowance for age, education, study center, body mass index, and approximate total energy intake, no significant associations between alcohol intake and the risk of cancer of the colon or rectum were found (odds ratios [OR] for greater-than-or-equal-to 42 drinks/week cf none = 1.0 (95 percent confidence interval [CI] = 0.8-1.4) and 0.7 (CI = 0.5-1.0) for cancer of the colon and rectum, respectively). A significant increase in the risk of colon cancer with increasing alcohol consumption was, however, observed in females (OR for greater-than-or-equal-to 28 drinks/week cf none = 1.8 (CI = 1.1-3.0). While the results of the present case-control study do not suggest that alcohol plays a role in the etiology of colon or rectum cancer overall, they provide a hint for a weak association between alcohol consumption and colon cancer among females which, because of the similarities with breast cancer, should be evaluated in the context of the possible relationship between colon cancer, alcohol intake, and female hormones.

引用

页码：153 / 159

页数：7

共 41 条

[11]

Kune S., Kune G.A., Watson L.F., Case-control study of alcoholic beverages as etiological factors: The Melbourne Colorectal Cancer Study, Nutr Cancer, 9, pp. 43-56, (1987)

[12]

Tuyns A.J., Pequinot G., Gignoux M., Valla A., Cancers of the digestive tract, alcohol and tobacco, Int J Cancer, 30, pp. 9-11, (1982)

[13]

Freudenheim J., Graham S., Marshall J., Haughey B., Wilkinson G., Alcohol consumption and rectal cancer: a case-control study, Am J Epidemiol, 128, pp. 890-1, (1988)

[14]

Kabat G.C., Howson C.P., Wynder E.L., Beer consumption and rectal cancer, Int J Epidemiol, 15, pp. 494-501, (1986)

[15]

Longnecker M.P., A case-control study of alcoholic beverage consumption in relation to risk of cancer of the right colon and rectum in men, Cancer Causes Control, 1, pp. 5-14, (1990)

[16]

Manousos O., Day N.E., Trichopoulos D., Gerovassilis F., Tzonou A., Polychronopoulou A., Diet and colorectal cancer: a case-control study in Greece, Int J Cancer, 32, pp. 1-5, (1983)

[17]

Martinez I., Torres R., Frias Z., Colon J.R., Fernandez N., Factors associated with adenocarcinomas of the large bowel in Puerto Rico, Adv Med Oncol Res Educ, 3, pp. 45-52, (1982)

[18]

Graham S., Marshall J., Haughey B., Et al., Dietary epidemiology of cancer of the colon in western New York, Am J Epidemiol, 128, pp. 490-503, (1988)

[19]

Macquart-Moulin G., Riboli E., Cornee J., Charnay B., Berthezene P., Day N., Case-control study on colorectal cancer and diet in Marseilles, Int J Cancer, 38, pp. 183-91, (1986)

[20]

Benito E., Obrador A., Stiggelbout A., Et al., A population-based case-control study of colorectal cancer in Majorca. I. Dietary factors, Int J Cancer, 45, pp. 69-76, (1990)

← 1 2 3 4 5 →