HIGH-DOSE L-CARNITINE IMPROVES IMMUNOLOGICAL AND METABOLIC PARAMETERS IN AIDS PATIENTS

被引：50

作者：

DESIMONE, C ^{[1
]}

TZANTZOGLOU, S ^{[1
]}

FAMULARO, G ^{[1
]}

MORETTI, S ^{[1
]}

PAOLETTI, F ^{[1
]}

VULLO, V ^{[1
]}

DELIA, S ^{[1
]}

机构：

[1] UNIV ROMA LA SAPIENZA,I-00185 ROME,ITALY

来源：

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY | 1993年 / 15卷 / 01期

关键词：

D O I：

10.3109/08923979309066930

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Several reports indicate that systemic carnitine deficiency could occur in acquired immunodeficiency disease syndrome (AIDS), and that primary and secondary carnitine deficiency leads to critical metabolic dysfunctions. L-carnitine supplementation to peripheral blood mononuclear cells (PBMCs) of AIDS patients resulted in significant enhancement of the phytohemagglutinin (PHA)-driven proliferative response. High dose L-carnitine administration (6 gr per day for two weeks) to AIDS patients treated with zidovudine also led to increased PBMCs proliferation and reduced blood levels of triglycerides. In addition, a reduction of beta2-microglobulin serum levels as well as circulating tumor necrosis factor (TNF)-alpha, mostly in patients exhibiting highly elevated levels, were found at the end of the treatment period. Our data suggest that in vivo L-carnitine could prove useful in ameliorating both the immune response and lipid metabolism in patients with AIDS, irrespective of initial serum carnitines levels. The mechanism(s) accounting for the observed results are currently not clear. Further studies are needed to confirm the hypothesis that L-carnitine affects the expression of HIV-induced cytokines.

引用

页码：1 / 12

页数：12

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[11] SELECTIVE DEFECTS IN CYTOMEGALOVIRUS-INDUCED AND MITOGEN-INDUCED LYMPHOCYTE-PROLIFERATION AND INTERFERON RELEASE IN PATIENTS WITH ACQUIRED IMMUNODEFICIENCY SYNDROME [J].