ANTISENSE OLIGODEOXYNUCLEOTIDE REDUCES BRAIN DOPAMINE-D2 RECEPTORS - BEHAVIORAL-CORRELATES

被引：144

作者：

ZHANG, M ^{[1
]}

CREESE, I ^{[1
]}

机构：

[1] RUTGERS UNIV, CTR MOLEC & BEHAV NEUROSCI, 197 UNIV AVE, NEWARK, NJ 07102 USA

来源：

NEUROSCIENCE LETTERS | 1993年 / 161卷 / 02期

关键词：

DOPAMINE-D2; RECEPTOR; ANTISENSE OLIGODEOXYNUCLEOTIDE; CATALEPSY; LOCOMOTOR ACTIVITY; QUINPIROLE; SKF38393;

D O I：

10.1016/0304-3940(93)90299-Z

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Intraventricular infusion of an antisense oligodeoxynucleotide corresponding to the rat dopamine D2 receptor mRNA reduced rat striatal D2 receptors by 48%, as measured by homogenate binding assays, while D1, muscarinic, and serotonin 5-HT2 receptors were unaffected. D2 receptor autoradiography indicated a homogeneous down-regulation of about 50% throughout the striatum and over 70% in the nucleus accumbens. A random oligodeoxynucleotide failed to affect either striatal D2 or D1 receptor density. The antisense treatment inhibited the D2 receptor agonist quinpirole-induced locomotor activation, without altering grooming behavior induced by SKF38393, a D1 receptor agonist. Antisense treatment also elicited catalepsy and reduced spontaneous locomotor activity.

引用

页码：223 / 226

页数：4