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FUNCTIONAL-PROPERTIES OF INTRACELLULAR CALCIUM-RELEASE CHANNELS

被引：47
作者：
EHRLICH, BE
机构：
[1] Laboratory of Molecular Hermeneutics, Department of Physiology, University of Connecticut, Farmington, CT 06030-3505
来源：
CURRENT OPINION IN NEUROBIOLOGY | 1995年 / 5卷 / 03期
关键词：
D O I：
10.1016/0959-4388(95)80042-5
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Two major classes of intracellular calcium-release channels have been identified, the ryanodine receptor and the inositol 1,4,5-trisphosphate receptor. These channels are the largest ion channels identified to date. Recent studies have established that approximately 90% of each of these proteins protrudes into the cytoplasm, presumably exposing many regulatory sites on the channel and allowing functional interactions with other cytoplasmic proteins. Current work is aimed at understanding the molecular mechanisms and cellular roles of these regulatory processes.
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页码：304 / 309
页数：6
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