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NONCOMPETITIVE INHIBITION OF GROUP-I INTRON RNA SELF-SPLICING BY AMINOGLYCOSIDE ANTIBIOTICS
被引:116
作者
:
VONAHSEN, U
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV VIENNA, INST MIKROBIOL & GENET, A-1090 VIENNA, AUSTRIA
VONAHSEN, U
DAVIES, J
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV VIENNA, INST MIKROBIOL & GENET, A-1090 VIENNA, AUSTRIA
DAVIES, J
SCHROEDER, R
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV VIENNA, INST MIKROBIOL & GENET, A-1090 VIENNA, AUSTRIA
SCHROEDER, R
机构
:
[1]
UNIV VIENNA, INST MIKROBIOL & GENET, A-1090 VIENNA, AUSTRIA
[2]
UNIV BRITISH COLUMBIA, DEPT MICROBIOL, VANCOUVER V6T 1Z3, BC, CANADA
来源
:
JOURNAL OF MOLECULAR BIOLOGY
|
1992年
/ 226卷
/ 04期
基金
:
奥地利科学基金会;
关键词
:
AUTOCATALYTIC RNA;
2-DEOXYSTREPTAMINE;
RIBOZYME;
RIBOSOME;
D O I
:
10.1016/0022-2836(92)91043-O
中图分类号
:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号
:
071010 ;
081704 ;
摘要
:
Aminoglycoside antibiotics inhibit self-splicing of group I intron RNA in vitro at concentrations as low as 10-6 m. The sites of interaction and the mechanism of inhibition have yet to be determined. A comparative study of inhibition by different 2-deoxystreptamine analogues reveals structural features of the aminoglycoside antibiotics required for their interaction and effect on group I introns. Complete antibiotic inhibition of the two steps of splicing was not reversed at high concentrations of guanosine, indicating a non-competitive inhibition. A mutant group I intron in which the conserved guanosine nucleotide of the G-binding site had been replaced by an adenosine, was sensitive to the antibiotics providing direct evidence that the antibiotics do not interact with the G-binding site in the same way as the guanine base. In addition kinetic analyses of the self-splicing process in the presence of antibiotic inhibitors supported a non-competitive mechanism of the mixed type for inhibition of the ribozyme. © 1992.
引用
收藏
页码:935 / 941
页数:7
相关论文
共 24 条
[11]
MODELING OF THE 3-DIMENSIONAL ARCHITECTURE OF GROUP-I CATALYTIC INTRONS BASED ON COMPARATIVE SEQUENCE-ANALYSIS
MICHEL, F
论文数:
0
引用数:
0
h-index:
0
机构:
CNRS,INST BIOL MOLEC & CELLULAIRE,F-67084 STRASBOURG,FRANCE
CNRS,INST BIOL MOLEC & CELLULAIRE,F-67084 STRASBOURG,FRANCE
MICHEL, F
WESTHOF, E
论文数:
0
引用数:
0
h-index:
0
机构:
CNRS,INST BIOL MOLEC & CELLULAIRE,F-67084 STRASBOURG,FRANCE
CNRS,INST BIOL MOLEC & CELLULAIRE,F-67084 STRASBOURG,FRANCE
WESTHOF, E
[J].
JOURNAL OF MOLECULAR BIOLOGY,
1990,
216
(03)
: 585
-
610
[12]
INTERACTION OF ANTIBIOTICS WITH FUNCTIONAL SITES IN 16S RIBOSOMAL-RNA
MOAZED, D
论文数:
0
引用数:
0
h-index:
0
MOAZED, D
NOLLER, HF
论文数:
0
引用数:
0
h-index:
0
NOLLER, HF
[J].
NATURE,
1987,
327
(6121)
: 389
-
394
[13]
DELETION-TOLERANCE AND TRANS-SPLICING OF THE BACTERIOPHAGE-T4 TD INTRON - ANALYSIS OF THE P6-L6A REGION
SALVO, JLG
论文数:
0
引用数:
0
h-index:
0
机构:
UNION UNIV,DEPT MICROBIOL & IMMUNOL,ALBANY,NY 12208
SALVO, JLG
COETZEE, T
论文数:
0
引用数:
0
h-index:
0
机构:
UNION UNIV,DEPT MICROBIOL & IMMUNOL,ALBANY,NY 12208
COETZEE, T
BELFORT, M
论文数:
0
引用数:
0
h-index:
0
机构:
UNION UNIV,DEPT MICROBIOL & IMMUNOL,ALBANY,NY 12208
BELFORT, M
[J].
JOURNAL OF MOLECULAR BIOLOGY,
1990,
211
(03)
: 537
-
549
[14]
EFFECTS OF MUTATIONS OF THE BULGED NUCLEOTIDE IN THE CONSERVED P7 PAIRING ELEMENT OF THE PHAGE-T4 TD INTRON ON RIBOZYME FUNCTION
SCHROEDER, R
论文数:
0
引用数:
0
h-index:
0
机构:
NEW YORK STATE DEPT HLTH,WADSWORTH CTR LABS & RES,EMPIRE STATE PLAZA,POB 509,ALBANY,NY 12201
SCHROEDER, R
VONAHSEN, U
论文数:
0
引用数:
0
h-index:
0
机构:
NEW YORK STATE DEPT HLTH,WADSWORTH CTR LABS & RES,EMPIRE STATE PLAZA,POB 509,ALBANY,NY 12201
VONAHSEN, U
BELFORT, M
论文数:
0
引用数:
0
h-index:
0
机构:
NEW YORK STATE DEPT HLTH,WADSWORTH CTR LABS & RES,EMPIRE STATE PLAZA,POB 509,ALBANY,NY 12201
BELFORT, M
[J].
BIOCHEMISTRY,
1991,
30
(13)
: 3295
-
3303
[15]
STRUCTURAL CONSERVATION AMONG 3 HOMOLOGOUS INTRONS OF BACTERIOPHAGE-T4 AND THE GROUP-I INTRONS OF EUKARYOTES
SHUB, DA
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MONTREAL,DEPT BIOCHIM,MONTREAL H3C 3J7,QUEBEC,CANADA
SHUB, DA
GOTT, JM
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MONTREAL,DEPT BIOCHIM,MONTREAL H3C 3J7,QUEBEC,CANADA
GOTT, JM
XU, MQ
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MONTREAL,DEPT BIOCHIM,MONTREAL H3C 3J7,QUEBEC,CANADA
XU, MQ
LANG, BF
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MONTREAL,DEPT BIOCHIM,MONTREAL H3C 3J7,QUEBEC,CANADA
LANG, BF
MICHEL, F
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MONTREAL,DEPT BIOCHIM,MONTREAL H3C 3J7,QUEBEC,CANADA
MICHEL, F
TOMASCHEWSKI, J
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MONTREAL,DEPT BIOCHIM,MONTREAL H3C 3J7,QUEBEC,CANADA
TOMASCHEWSKI, J
PEDERSENLANE, J
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MONTREAL,DEPT BIOCHIM,MONTREAL H3C 3J7,QUEBEC,CANADA
PEDERSENLANE, J
BELFORT, M
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MONTREAL,DEPT BIOCHIM,MONTREAL H3C 3J7,QUEBEC,CANADA
BELFORT, M
[J].
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1988,
85
(04)
: 1151
-
1155
[16]
A SELF-SPLICING INTRON IN THE SMALL SUBUNIT RIBOSOMAL-RNA GENE OF PNEUMOCYSTIS-CARINII
SOGIN, ML
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV COLORADO,HLTH SCI CTR,DEPT MICROBIOL & IMMUNOL,DENVER,CO 80206
SOGIN, ML
EDMAN, JC
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV COLORADO,HLTH SCI CTR,DEPT MICROBIOL & IMMUNOL,DENVER,CO 80206
EDMAN, JC
[J].
NUCLEIC ACIDS RESEARCH,
1989,
17
(13)
: 5349
-
5359
[17]
MODEL FOR THE 3-DIMENSIONAL FOLDING OF 16-S RIBOSOMAL-RNA
STERN, S
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SANTA CRUZ,THIMANN LABS,SANTA CRUZ,CA 95064
UNIV CALIF SANTA CRUZ,THIMANN LABS,SANTA CRUZ,CA 95064
STERN, S
WEISER, B
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SANTA CRUZ,THIMANN LABS,SANTA CRUZ,CA 95064
UNIV CALIF SANTA CRUZ,THIMANN LABS,SANTA CRUZ,CA 95064
WEISER, B
NOLLER, HF
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SANTA CRUZ,THIMANN LABS,SANTA CRUZ,CA 95064
UNIV CALIF SANTA CRUZ,THIMANN LABS,SANTA CRUZ,CA 95064
NOLLER, HF
[J].
JOURNAL OF MOLECULAR BIOLOGY,
1988,
204
(02)
: 447
-
481
[18]
Tanaka N, 1982, AMINOGLYCOSIDE ANTIB, P221
[19]
VONAHSEN U, 1990, NATURE, V346, P801
[20]
STREPTOMYCIN INHIBITS SPLICING OF GROUP-I INTRONS BY COMPETITION WITH THE GUANOSINE SUBSTRATE
VONAHSEN, U
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV VIENNA,INST MIKROBIOL & GENET,ALTHANSTR 14,A-1090 VIENNA,AUSTRIA
UNIV VIENNA,INST MIKROBIOL & GENET,ALTHANSTR 14,A-1090 VIENNA,AUSTRIA
VONAHSEN, U
SCHROEDER, R
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV VIENNA,INST MIKROBIOL & GENET,ALTHANSTR 14,A-1090 VIENNA,AUSTRIA
UNIV VIENNA,INST MIKROBIOL & GENET,ALTHANSTR 14,A-1090 VIENNA,AUSTRIA
SCHROEDER, R
[J].
NUCLEIC ACIDS RESEARCH,
1991,
19
(09)
: 2261
-
2265
←
1
2
3
→
共 24 条
[11]
MODELING OF THE 3-DIMENSIONAL ARCHITECTURE OF GROUP-I CATALYTIC INTRONS BASED ON COMPARATIVE SEQUENCE-ANALYSIS
MICHEL, F
论文数:
0
引用数:
0
h-index:
0
机构:
CNRS,INST BIOL MOLEC & CELLULAIRE,F-67084 STRASBOURG,FRANCE
CNRS,INST BIOL MOLEC & CELLULAIRE,F-67084 STRASBOURG,FRANCE
MICHEL, F
WESTHOF, E
论文数:
0
引用数:
0
h-index:
0
机构:
CNRS,INST BIOL MOLEC & CELLULAIRE,F-67084 STRASBOURG,FRANCE
CNRS,INST BIOL MOLEC & CELLULAIRE,F-67084 STRASBOURG,FRANCE
WESTHOF, E
[J].
JOURNAL OF MOLECULAR BIOLOGY,
1990,
216
(03)
: 585
-
610
[12]
INTERACTION OF ANTIBIOTICS WITH FUNCTIONAL SITES IN 16S RIBOSOMAL-RNA
MOAZED, D
论文数:
0
引用数:
0
h-index:
0
MOAZED, D
NOLLER, HF
论文数:
0
引用数:
0
h-index:
0
NOLLER, HF
[J].
NATURE,
1987,
327
(6121)
: 389
-
394
[13]
DELETION-TOLERANCE AND TRANS-SPLICING OF THE BACTERIOPHAGE-T4 TD INTRON - ANALYSIS OF THE P6-L6A REGION
SALVO, JLG
论文数:
0
引用数:
0
h-index:
0
机构:
UNION UNIV,DEPT MICROBIOL & IMMUNOL,ALBANY,NY 12208
SALVO, JLG
COETZEE, T
论文数:
0
引用数:
0
h-index:
0
机构:
UNION UNIV,DEPT MICROBIOL & IMMUNOL,ALBANY,NY 12208
COETZEE, T
BELFORT, M
论文数:
0
引用数:
0
h-index:
0
机构:
UNION UNIV,DEPT MICROBIOL & IMMUNOL,ALBANY,NY 12208
BELFORT, M
[J].
JOURNAL OF MOLECULAR BIOLOGY,
1990,
211
(03)
: 537
-
549
[14]
EFFECTS OF MUTATIONS OF THE BULGED NUCLEOTIDE IN THE CONSERVED P7 PAIRING ELEMENT OF THE PHAGE-T4 TD INTRON ON RIBOZYME FUNCTION
SCHROEDER, R
论文数:
0
引用数:
0
h-index:
0
机构:
NEW YORK STATE DEPT HLTH,WADSWORTH CTR LABS & RES,EMPIRE STATE PLAZA,POB 509,ALBANY,NY 12201
SCHROEDER, R
VONAHSEN, U
论文数:
0
引用数:
0
h-index:
0
机构:
NEW YORK STATE DEPT HLTH,WADSWORTH CTR LABS & RES,EMPIRE STATE PLAZA,POB 509,ALBANY,NY 12201
VONAHSEN, U
BELFORT, M
论文数:
0
引用数:
0
h-index:
0
机构:
NEW YORK STATE DEPT HLTH,WADSWORTH CTR LABS & RES,EMPIRE STATE PLAZA,POB 509,ALBANY,NY 12201
BELFORT, M
[J].
BIOCHEMISTRY,
1991,
30
(13)
: 3295
-
3303
[15]
STRUCTURAL CONSERVATION AMONG 3 HOMOLOGOUS INTRONS OF BACTERIOPHAGE-T4 AND THE GROUP-I INTRONS OF EUKARYOTES
SHUB, DA
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MONTREAL,DEPT BIOCHIM,MONTREAL H3C 3J7,QUEBEC,CANADA
SHUB, DA
GOTT, JM
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MONTREAL,DEPT BIOCHIM,MONTREAL H3C 3J7,QUEBEC,CANADA
GOTT, JM
XU, MQ
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MONTREAL,DEPT BIOCHIM,MONTREAL H3C 3J7,QUEBEC,CANADA
XU, MQ
LANG, BF
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MONTREAL,DEPT BIOCHIM,MONTREAL H3C 3J7,QUEBEC,CANADA
LANG, BF
MICHEL, F
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MONTREAL,DEPT BIOCHIM,MONTREAL H3C 3J7,QUEBEC,CANADA
MICHEL, F
TOMASCHEWSKI, J
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MONTREAL,DEPT BIOCHIM,MONTREAL H3C 3J7,QUEBEC,CANADA
TOMASCHEWSKI, J
PEDERSENLANE, J
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MONTREAL,DEPT BIOCHIM,MONTREAL H3C 3J7,QUEBEC,CANADA
PEDERSENLANE, J
BELFORT, M
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MONTREAL,DEPT BIOCHIM,MONTREAL H3C 3J7,QUEBEC,CANADA
BELFORT, M
[J].
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1988,
85
(04)
: 1151
-
1155
[16]
A SELF-SPLICING INTRON IN THE SMALL SUBUNIT RIBOSOMAL-RNA GENE OF PNEUMOCYSTIS-CARINII
SOGIN, ML
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV COLORADO,HLTH SCI CTR,DEPT MICROBIOL & IMMUNOL,DENVER,CO 80206
SOGIN, ML
EDMAN, JC
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV COLORADO,HLTH SCI CTR,DEPT MICROBIOL & IMMUNOL,DENVER,CO 80206
EDMAN, JC
[J].
NUCLEIC ACIDS RESEARCH,
1989,
17
(13)
: 5349
-
5359
[17]
MODEL FOR THE 3-DIMENSIONAL FOLDING OF 16-S RIBOSOMAL-RNA
STERN, S
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SANTA CRUZ,THIMANN LABS,SANTA CRUZ,CA 95064
UNIV CALIF SANTA CRUZ,THIMANN LABS,SANTA CRUZ,CA 95064
STERN, S
WEISER, B
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SANTA CRUZ,THIMANN LABS,SANTA CRUZ,CA 95064
UNIV CALIF SANTA CRUZ,THIMANN LABS,SANTA CRUZ,CA 95064
WEISER, B
NOLLER, HF
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SANTA CRUZ,THIMANN LABS,SANTA CRUZ,CA 95064
UNIV CALIF SANTA CRUZ,THIMANN LABS,SANTA CRUZ,CA 95064
NOLLER, HF
[J].
JOURNAL OF MOLECULAR BIOLOGY,
1988,
204
(02)
: 447
-
481
[18]
Tanaka N, 1982, AMINOGLYCOSIDE ANTIB, P221
[19]
VONAHSEN U, 1990, NATURE, V346, P801
[20]
STREPTOMYCIN INHIBITS SPLICING OF GROUP-I INTRONS BY COMPETITION WITH THE GUANOSINE SUBSTRATE
VONAHSEN, U
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV VIENNA,INST MIKROBIOL & GENET,ALTHANSTR 14,A-1090 VIENNA,AUSTRIA
UNIV VIENNA,INST MIKROBIOL & GENET,ALTHANSTR 14,A-1090 VIENNA,AUSTRIA
VONAHSEN, U
SCHROEDER, R
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV VIENNA,INST MIKROBIOL & GENET,ALTHANSTR 14,A-1090 VIENNA,AUSTRIA
UNIV VIENNA,INST MIKROBIOL & GENET,ALTHANSTR 14,A-1090 VIENNA,AUSTRIA
SCHROEDER, R
[J].
NUCLEIC ACIDS RESEARCH,
1991,
19
(09)
: 2261
-
2265
←
1
2
3
→