DNA GYRASE - STRUCTURE AND FUNCTION

被引：599

作者：

REECE, RJ ^{[1
]}

MAXWELL, A ^{[1
]}

机构：

[1] UNIV LEICESTER, DEPT BIOCHEM, LEICESTER LE1 7RH, ENGLAND

来源：

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY | 1991年 / 26卷 / 3-4期

关键词：

DNA GYRASE; DNA-PROTEIN INTERACTIONS; ENERGY COUPLING; DNA TOPOISOMERASES; SUPERCOILED DNA;

D O I：

10.3109/10409239109114072

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

DNA gyrase is an essential bacterial enzyme that catalyzes the ATP-dependent negative super-coiling of double-stranded closed-circular DNA. Gyrase belongs to a class of enzymes known as topoisomerases that are involved in the control of topological transitions of DNA. The mechanism by which gyrase is able to influence the topological state of DNA molecules is of inherent interest from an enzymological standpoint. In addition, much attention has been focused on DNA gyrase as the intracellular target of a number of antibacterial agents and as a paradigm for other DNA topoisomerases. In this review we summarize the current knowledge concerning DNA gyrase by addressing a wide range of aspects of the study of this enzyme.

引用

页码：335 / 375

页数：41

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