A CONVENIENT SYNTHESIS OF 2-BUTYL-4(5)-CHLORO-1H-IMIDAZOLE-5(4)-CARBOXALDEHYDE

被引：12

作者：

WATSON, SP

机构：

[1] Glaxo Group Research, Ware, Hertfordshire SG12 ODJ, Park Road

来源：

SYNTHETIC COMMUNICATIONS | 1992年 / 22卷 / 20期

关键词：

D O I：

10.1080/00397919208021123

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A Convenient Synthesis of 2-Butyl-4(5)-chloro-1H-imidazole-5(4)-carboxaldehyde, starting from 2-butyl imidazole, has been developed.

引用

页码：2971 / 2977

页数：7

共 7 条

[1] NONPEPTIDE ANGIOTENSIN-II RECEPTOR ANTAGONISTS - THE DISCOVERY OF A SERIES OF N-(BIPHENYLYLMETHYL)IMIDAZOLES AS POTENT, ORALLY ACTIVE ANTIHYPERTENSIVES [J].

CARINI, DJ ;

DUNCIA, JV ;

ALDRICH, PE ;

CHIU, AT ;

JOHNSON, AL ;

PIERCE, ME ;

PRICE, WA ;

SANTELLA, JB ;

WELLS, GJ ;

WEXLER, RR ;

WONG, PC ;

YOO, SE ;

TIMMERMANS, PBMWM .

JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (08) :2525-2547

[2]

FURUKAWA Y, 1982, Patent No. 4355040

[3]

HUGHEY JL, 1980, SYNTHESIS-STUTTGART, P489

[4] NOVEL HALOGENATED IMIDAZOLES . CHLOROIMIDAZOLES [J].

LUTZ, AW ;

DELORENZ.S .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1967, 4 (03) :399-&

[5] BROMOBENZOFURANS - A NEW CLASS OF POTENT, NONPEPTIDE ANTAGONISTS OF ANGIOTENSIN-II [J].

MIDDLEMISS, D ;

DREW, GM ;

ROSS, BC ;

ROBERTSON, MJ ;

SCOPES, DIC ;

DOWLE, MD ;

AKERS, J ;

CARDWELL, K ;

CLARK, KL ;

COOTE, S ;

ELDRED, CD ;

HAMBLETT, J ;

HILDITCH, A ;

HIRST, GC ;

JACK, T ;

MONTANA, J ;

PANCHAL, TA ;

PATON, JMS ;

SHAH, P ;

STUART, G ;

TRAVERS, A .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1991, 1 (12) :711-716

[6]

PAULY H, 1908, CHEM BER, V41, P3999

[7] 1-(CARBOXYBENZYL)IMIDAZOLE-5-ACRYLIC ACIDS - POTENT AND SELECTIVE ANGIOTENSIN-II RECEPTOR ANTAGONISTS [J].

WEINSTOCK, J ;

KEENAN, RM ;

SAMANEN, J ;

HEMPEL, J ;

FINKELSTEIN, JA ;

FRANZ, RG ;

GAITANOPOULOS, DE ;

GIRARD, GR ;

GLEASON, JG ;

HILL, DT ;

MORGAN, TM ;

PEISHOFF, CE ;

AIYAR, N ;

BROOKS, DP ;

FREDRICKSON, TA ;

OHLSTEIN, EH ;

RUFFOLO, RR ;

STACK, EJ ;

SULPIZIO, AC ;

WEIDLEY, EF ;

EDWARDS, RM .

JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (04) :1514-1517

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