SYNTHESIS OF AN OXYAMIDE LINKED NUCLEOTIDE DIMER AND INCORPORATION INTO ANTISENSE OLIGONUCLEOTIDE SEQUENCES

被引：26

作者：

BURGESS, K ^{[1
]}

GIBBS, RA ^{[1
]}

METZKER, ML ^{[1
]}

RAGHAVACHARI, R ^{[1
]}

机构：

[1] BAYLOR COLL MED, INST MOLEC GENET, HOUSTON, TX 77030 USA

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1994年 / 08期

关键词：

D O I：

10.1039/c39940000915

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two derivatives of thymidine, a 5'-protected 3'-hydroxylamine and 5'-carboxy-3'-protected compound, were prepared and coupled to form an oxyamide-linked dinucleotide analogue; this dimer was incorporated into an oligodeoxynucleotide then shown to anneal to complementary DNA with nearly the same affinity as the natural sequence.

引用

页码：915 / 916

页数：2

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