INHIBITION OF LEUKOTRIENE-B4 FORMATION IN RAT PERITONEAL NEUTROPHILS BY AN ETHANOLIC EXTRACT OF THE GUM RESIN EXUDATE OF BOSWELLIA-SERRATA

被引：146

作者：

AMMON, HPT ^{[1
]}

MACK, T ^{[1
]}

SINGH, GB ^{[1
]}

SAFAYHI, H ^{[1
]}

机构：

[1] REG RES LAB,DEPT PHARMACOL,JAMMU 180001,INDIA

来源：

PLANTA MEDICA | 1991年 / 57卷 / 03期

关键词：

5-LIPOXYGENASE; LEUKOTRIENES; BOSWELLIA-SERRATA; SALAI GUGGAL;

D O I：

10.1055/s-2006-960074

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Suspensions of rat peritoneal polymorphonuclear leukocytes (PMNL) elicited with glycogen were stimulated by calcium and ionophore to produce leukotrienes and 5-HETE from endogenous arachidonic acid (AA). We investigated the effect of ethanolic extracts of the gum resin exudate of Boswellia serrata. A concentration-dependent inhibition of LTB4 and 5-HETE production by different charges of exudate extracts were found. All products of the 5-lipoxygenase (5-LOx) from endogenous arachidonic acid (AA) in PMNL were reduced to the same extent by the extracts tested. The ethanolic extract of the gum resin also decreased 5-LOx mediated metabolisation of exogenously added AA to LTB4 and 5-HETE. Since steroidal-type anti-inflammatory drugs do not exert an immediate effect in the test system used, we conclude that the activity of the 5-LOx itself represents the side of inhibition by the gum resin extract. Therefore, an inhibition of 5-LOx catalysed mediator synthesis might be involved in the previously reported anti-inflammatory activity in vivo.

引用

页码：203 / 207

页数：5

共 18 条

[11] A NOVEL BIOLOGICALLY-ACTIVE SELENO-ORGANIC COMPOUND .5. INHIBITION BY EBSELEN (PZ-51) OF RAT PERITONEAL NEUTROPHIL LIPOXYGENASE [J].