THE USE OF C-13-LABELING TO PROVE THAT CREATININE IS OXIDIZED BY MAMMALS INTO CREATOL AND 5-HYDROXY-1-METHYLHYDANTOIN

被引：40

作者：

IENAGA, K

NAKAMURA, K

YAMAKAWA, M

TOYOMAKI, Y

MATSUURA, H

YOKOZAWA, T

OURA, H

NAKANO, K

机构：

[1] TOYAMA MED & PHARMACEUT UNIV,WAKAN YAKU RES INST,SUGITANI,TOYAMA 93001,JAPAN

[2] KYOTO PREFECTURAL UNIV MED,DEPT INTERNAL MED 1,KYOTO 602,JAPAN

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1991年 / 07期

关键词：

D O I：

10.1039/c39910000509

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Creatinine 1 is not an end-metabolite but a precursor for three heterocycles, 2-amino-5-hydroxy-1-methyl-4(5H)-imidazolone (creatol) 2, 1-methylimidazolidine-2,4-dione 4 and its 5-hydroxy derivative 5; this is now proven directly by administration of [Me-C-13]creatinine 1, to a uraemic rat and subsequent isolation of the corresponding labelled metabolites 2, 4 and 5 from its urine.

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页码：509 / 510

页数：2

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