SYNTHESIS OF RIBOFURANOSIDES BY CATALYSIS WITH LEWIS-ACIDS - GLYCOSIDATION VERSUS TRANSACETYLATION

被引：22

作者：

CHIUMACHADO, I

CASTROPALOMINO, JC

MADRAZOALONSO, O

LOPETEGUIPALACIOS, C

VEREZBENCOMO, V

机构：

[1] UNIV LA HABANA,FAC QUIM,SYNTHET ANTIGENS LAB,HAVANA 10400,CUBA

[2] INST FINLAY SUEROS & VACUNAS,HAVANA 11600,CUBA

来源：

JOURNAL OF CARBOHYDRATE CHEMISTRY | 1995年 / 14卷 / 4-5期

关键词：

D O I：

10.1080/07328309508005357

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several ribofuranosyl derivatives bearing trichloroacetimidoyl or acetyl leaving groups in a Lewis acid promoted ribosylation reaction were prepared and used in an attempt to improve the yield and to avoid donor --> acceptor transacetylation. Trichloroacetimidates were excellent donors affording disaccharides with very high yields under mild conditions. The corresponding 1-O-acetylated analogs could also be used with out transacetylation in the presence of boron trifluoride etherate.

引用

页码：551 / 561

页数：11