2,4-DIAMINOTHIENO [2,3-D] PYRIMIDINES AS ANTIFOLATES AND ANTIMALARIALS .3. SYNTHESIS OF 5,6-DISUBSTITUTED DERIVATIVES AND RELATED TETRACYCLIC ANALOGS

被引：49

作者：

ROSOWSKY, A

CHEN, KKN

LIN, M

机构：

[1] CHILDRENS CANC RES FDN,BOSTON,MA 02115

[2] HARVARD UNIV,MED SCH,DEPT BIOL CHEM,BOSTON,MA 02115

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1973年 / 16卷 / 03期

关键词：

D O I：

10.1021/jm00261a004

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：191 / 194

页数：4

共 13 条

[1]

BINOVIC K, 1968, Chimica Therapeutica, V3, P313

[2] SYNTHESIS OF KETONES OF TYPE CH3COCH2R FROM ACETYLACETONE AND HALIDES WITH ETHANOLIC POTASSIUM CARBONATE . AN ALKYLATION-CLEAVAGE PROCESS [J].

BOATMAN, S ;

HARRIS, TM ;

HAUSER, CR .

JOURNAL OF ORGANIC CHEMISTRY, 1965, 30 (10) :3321-&

[3] RING CLOSURE OF YLIDENEMALONONITRILES [J].

CAMPAIGNE, E ;

KREIGHBA.WE ;

MAULDING, DR ;

BULBENKO, GF .

JOURNAL OF ORGANIC CHEMISTRY, 1962, 27 (12) :4428-&

[4] 2,4-DIAMINOTHIENO [2,3-D] PYRIMIDINES AS ANTIFOLATES AND ANTIMALARIALS .2. SYNTHESIS OF 2,4-DIAMINOPYRIDO [4',3' - 4,5] THIENO [2,3-D] PYRIMIDINES AND 2,4-DIAMINO-8H-THIOPYRANO [4',3' - 4,5] THIENO [2,3-D] PYRIMIDINES [J].

CHAYKOVSKY, M ;

LIN, M ;

ROSOWSKY, A ;

MODEST, EJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1973, 16 (03) :188-191

[5] FOLATE ANTAGONISTS .6. SYNTHESIS AND ANTIMALARIAL EFFECTS OF FUSED "2,4-DIAMINOTHIENO[2,3-D]PYRIMIDINES [J].

ELSLAGER, EF ;

JACOB, P ;

WERBEL, LM .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1972, 9 (04) :775-&

[6] SOME DERIVATIVES OF 2,7-NAPHTHYRIDINE [J].

FERRIER, BM ;

CAMPBELL, N .

JOURNAL OF THE CHEMICAL SOCIETY, 1960, (SEP) :3513-3515

[7] A COMPARATIVE STUDY OF THE USE OF MICROORGANISMS IN THE SCREENING OF POTENTIAL ANTITUMOR AGENTS [J].

FOLEY, GE ;

MCCARTHY, RE ;

BINNS, VM ;

SNELL, EE ;

GUIRARD, BM ;

KIDDER, GW ;

DEWEY, VC ;

THAYER, PS .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1958, 76 (03) :413-441

[8] 2-AMINO-THIOPHENE AUS METHYLENAKTIVEN NITRILEN CARBONYLVERBINDUNGEN UND SCHWEFEL [J].

GEWALD, K ;

SCHINKE, E ;

BOTTCHER, H .

CHEMISCHE BERICHTE-RECUEIL, 1966, 99 (01) :94-&

[9] 2,4,7-TRIAMINO-6-ORTHO-SUBSTITUTED ARYLPTERIDINES . A NEW SERIES OF POTENT ANTIMALARIAL AGENTS [J].

OSDENE, TS ;

RUSSELL, PB ;

RANE, L .

JOURNAL OF MEDICINAL CHEMISTRY, 1967, 10 (03) :431-&

[10] 2,4-DIAMINOTHIENO[2,3-D] PYRIMIDINES AS ANTIFOLATES AND ANTIMALARIALS .1. SYNTHESIS OF 2,4-DIAMINO-5,6,7,8-TETRAHYDROTHIANAPHTHENO[2,3-D] PYRIMIDINES AND RELATED COMPOUNDS [J].

ROSOWSKY, A ;

CHAYKOVSKY, M ;

CHEN, KKN ;

LIN, M ;

MODEST, EJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1973, 16 (03) :185-188

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