REGIONAL DEPOSITION OF INHALED C-11 NICOTINE VAPOR IN THE HUMAN AIRWAY AS VISUALIZED BY POSITRON EMISSION TOMOGRAPHY

被引:79
作者
BERGSTROM, M
NORDBERG, A
LUNELL, E
ANTONI, G
LANGSTROM, B
机构
[1] UPPSALA UNIV, PET CTR, UPPSALA, SWEDEN
[2] HUDDINGE UNIV HOSP, KAROLINSKA INST, CTR NICOTINE RES, S-14186 HUDDINGE, SWEDEN
[3] PHARM RES LABS, HELSINGBORG, SWEDEN
[4] UNIV LUND HOSP, DEPT CLIN PHARMACOL, S-22185 LUND, SWEDEN
关键词
D O I
10.1016/0009-9236(95)90156-6
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The deposition of C-11-nicotine in the respiratory tract from a nicotine vapor inhaler was studied by means of positron emission tomography (PET) in an intrasubject comparison of six healthy smokers using two modes of inhalation: one with shallow, frequent inhalations (''buccal mode'') and one with deep inhalations (''pulmonary mode''). An average of 15% of the radioactivity was released from the vapor inhaler after 5 minutes of inhalation, Approximately 45% of the dose released was found in the oral cavity, A significant amount of radioactivity, 10%, was observed in the esophagus, suggesting transfer of a major fraction of the dose to the stomach, Only a minor fraction, 5%, was found in the lungs, followed by 2% in the bronchi and 1% in the trachea. The deposition in the oral cavity closely followed a linear pattern during the 5 minutes of inhalation and was followed by a rapid elimination from the oral cavity, with an average half-life of 18 minutes. Only 8% of the dose released remained in the oral cavity 45 minutes after the end of inhalation, On the other hand, the dose fraction of about 14% distributed into the body tissue compartment at the end of inhalation had risen to 60% at that late time point. No statistically or clinically important differences were observed between the buccal and the pulmonary mode of inhalation in either deposition pattern or elimination rates.
引用
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页码:309 / 317
页数:9
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