BETA-AMYLOID PROTEIN-INDUCED ALZHEIMERS-DISEASE ANIMAL-MODEL

被引：254

作者：

NITTA, A

ITOH, A

HASEGAWA, T

NABESHIMA, T

机构：

[1] NAGOYA UNIV,SCH MED,DEPT NEUROPSYCHOPHARMACOL,SHOWA KU,NAGOYA,AICHI 466,JAPAN

[2] NAGOYA UNIV,HOSP PHARM,SCH MED,SHOWA KU,NAGOYA,AICHI 466,JAPAN

来源：

NEUROSCIENCE LETTERS | 1994年 / 170卷 / 01期

关键词：

BETA-AMYLOID PROTEIN; ALZHEIMERS DISEASE; MEMORY; CHOLINE ACETYLTRANSFERASE; WATER MAZE; RAT;

D O I：

10.1016/0304-3940(94)90239-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To investigate the toxicity of beta-amyloid protein which consisted of senile plaques of Alzheimer's disease (AD), this was infused into cerebral ventricle for 14 days by using mini-osmotic pump. The performance of the water maze task in beta-amyloid protein-treated rats was impaired. Choline acetyltransferase activity significantly decreased in the frontal cortex and hippocampus. These results suggest that the deposition of beta-amyloid protein in the brain is related to the impairment of learning and cholinergic neuronal degeneration, and that beta-amyloid protein-treated rats could be used as an animal model for AD.

引用

页码：63 / 66

页数：4