EXPRESSION OF CHROMOGRANIN-A IN LESIONS IN THE CENTRAL-NERVOUS-SYSTEM FROM PATIENTS WITH NEUROLOGICAL DISEASES

被引：55

作者：

YASUHARA, O

KAWAMATA, T

AIMI, Y

MCGEER, EG

MCGEER, PL

机构：

[1] UNIV BRITISH COLUMBIA, KINSMEN LAB NEUROL RES, VANCOUVER V6T 1Z3, BC, CANADA

[2] UNIV BRITISH COLUMBIA, CTR NEURODEGENERAT DISORDERS, VANCOUVER V6T 1Z3, BC, CANADA

来源：

NEUROSCIENCE LETTERS | 1994年 / 170卷 / 01期

关键词：

CHROMOGRANIN A; ALZHEIMERS DISEASE; PICKS DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; MULTIPLE SYSTEM ATROPHY; DYSTROPHIC NEURITE; PICK BODY; SPHEROID BODY; TORPEDO FORMATION;

D O I：

10.1016/0304-3940(94)90227-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Expression of chromogranin A in various neurological diseases was examined immunohistochemically using purified anti-human chromogranin A antiserum. The antibody stained dystrophic neurites in senile plaques in Alzheimer disease brain, Pick bodies and ballooned neurons in Pick's disease brain, some Lewy bodies in the substantia nigra of Parkinson's disease, and axonal swellings in various neurological conditions including Parkinson's disease, striatonigral degeneration, Shy-Drager syndrome, amyotrophic lateral sclerosis and cerebral infarction. The present study shows that expression of chromogranin A is not an exclusive feature of Alzheimer disease or Pick's disease, and indicates that it could be a useful marker for various neurological diseases.

引用

页码：13 / 16

页数：4

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