BIOACTIVE AND OTHER PIPERIDINE ALKALOIDS FROM CASSIA-LEPTOPHYLLA

被引：64

作者：

BOLZANI, VD

GUNATILAKA, AAL

KINGSTON, DGI

机构：

[1] VIRGINIA POLYTECH INST & STATE UNIV,DEPT CHEM,BLACKSBURG,VA 24061

[2] UNIV ESTADUAL PAULISTA,INST QUIM,BR-14800 ARARAQUARA,SP,BRAZIL

来源：

TETRAHEDRON | 1995年 / 51卷 / 21期

关键词：

D O I：

10.1016/0040-4020(95)00254-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Four new piperidine alkaloids, leptophyllin A (4), 3-acetylleptophyllin A (5), leptophyllin B (8), and (-)-spectaline (1), and 3 known piperidine alkaloids, (-)-spectalinine (2), canavaline (3), and iso-6-canavaline (7), were isolated by a bioassay-guided fractionation of a leaf extract of Cassia leptophylla. The alkaloids 1 - 3 were active in a mechanism-based DNA-modifying yeast assay and 2 was moderately active in Vero monkey and Chinese hamster ovary cell cytotoxicity assays.

引用

页码：5929 / 5934

页数：6

共 11 条

[1]

AHMED VU, 1978, Z NATURFORSCH, V33, P347

[2]

BROWN E, 1972, B SOC CHIM FR, V11, P4292

[3] SPECTALININE AND ISO-6-CARNAVALINE, 2 UNPRECEDENTED PIPERIDINE ALKALOIDS FROM SEEDS OF CASSIA-SPECTABILIS [J].