CATALYSIS OF NUCLEOTIDE POLYMERIZATION BY COMPOUNDS OF DIVALENT LEAD

被引：40

作者：

SLEEPER, HL

ORGEL, LE

机构：

[1] The Salk Institute for Biological Studies, San Diego, 92112, California

来源：

JOURNAL OF MOLECULAR EVOLUTION | 1979年 / 12卷 / 04期

关键词：

Divalent lead; Nucleoside 5′-Phosphorimidazolides; Oligonucleotide synthesis; Prebiotic synthesis;

D O I：

10.1007/BF01732030

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Soluble lead salts and a number of lead-containing minerals catalyze the formation of oligonucleotides from nucleoside 5′-phosphorimidazolides. The effectiveness of lead compounds correlates strongly with their solubility. Under optimal conditions we were able to obtain 18% of pentamer and higher oligomers from ImpA. Reactions involving ImpU gave smaller yields. © 1979 Springer-Verlag.

引用

页码：357 / 364

页数：8