COMPARISON OF AMINO-ACID SEQUENCE OF BOVINE COAGULATION FACTOR-IX (CHRISTMAS FACTOR) WITH THAT OF OTHER VITAMIN-K-DEPENDENT PLASMA-PROTEINS

被引：161

作者：

KATAYAMA, K ^{[1
]}

ERICSSON, LH ^{[1
]}

ENFIELD, DL ^{[1
]}

WALSH, KA ^{[1
]}

NEURATH, H ^{[1
]}

DAVIE, EW ^{[1
]}

TITANI, K ^{[1
]}

机构：

[1] UNIV WASHINGTON, DEPT BIOCHEM, SEATTLE, WA 98195 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1979年 / 76卷 / 10期

关键词：

D O I：

10.1073/pnas.76.10.4990

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The amino acid sequence of bovine blood coagulation Factor IX (Christmas Factor) is presented and compared with the sequences of other vitamin K-dependent plasma proteins and pancreatic trypsinogen. The 416-residue sequence of Factor IX was determined largely by automated Edman degradation of two large segments, containing 181 and 235 residues, isolated after activating Factor IX with a protease from Russell's viper venom. Subfragments of the two segments were produced by enzymatic digestion and by chemical cleavage of methionyl, tryptophyl, and asparaginyl-glycyl bonds. Comparison of the amino acid sequences of factor IX, Factor X, and Protein C demonstrates that they are homologous throughout. Their homology with prothrombin, however, is restricted to the amino-terminal region, which is rich in γ-carboxyglutamic acid, and the carboxyl-terminal region, which represents the catalytic domain of these proteins and corresponds to that of pancreatic serine proteases.

引用

页码：4990 / 4994

页数：5

共 40 条

[1]

AGGELER PM, 1952, P SOC EXP BIOL MED, V79, P692

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