ACUTE PROMYELOCYTIC LEUKEMIA CASES WITH NONRECIPROCAL PML/RARA OR RARA/PML FUSION GENES

被引：58

作者：

LAFAGEPOCHITALOFF, M

ALCALAY, M

BRUNEL, V

LONGO, L

SAINTY, D

SIMONETTI, J

BIRG, F

PELICCI, PG

机构：

[1] UNIV PERUGIA,MONTELUCE POLICLIN,IST CLIN MED 1,I-06100 PERUGIA,ITALY

[2] INST J PAOLI I CALMETTES,F-13009 MARSEILLE,FRANCE

[3] INSERM,U119,MARSEILLE,FRANCE

来源：

BLOOD | 1995年 / 85卷 / 05期

关键词：

D O I：

10.1182/blood.V85.5.1169.1169

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Tumor-associated chromosome translocations usually lead to the formation of two reciprocal fusion genes: one thought to be involved in the transformation process, the other the mechanical consequence of the translocation event. In the case of acute promyelocytic leukemia (APL) blasts, the 15;17 chromosome translocation generates the putatively transforming PML/RARa fusion gene and its reciprocal RARa/PML. We report APL cases with submicroscopic 15;17 recombinations leading to the formation of nonreciprocal PML/RARa or RARa/PML fusion genes. Therefore, each of the two reciprocal translocation products may be independently formed and selected by the leukemic phenotype, implying that both are involved in tumorigenesis. (C) 1995 by The American Society of Hematology.

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页码：1169 / 1174

页数：6

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