PREDICTIVE VALUE OF FETAL SERUM BETA(2)-MICROGLOBULIN FOR NEONATAL RENAL-FUNCTION

被引：55

作者：

BERRY, SM

LECOLIER, B

SMITH, RS

BERCAU, G

DOMBROWSKI, MP

PUDER, KS

KITHIER, K

BIDAT, L

JOHNSON, MP

COTTON, DB

机构：

[1] WAYNE STATE UNIV,HUTZEL HOSP,RECEIVING HOSP,DEPT OBSTET & GYNAECOL,DIV REPROD GENET,DETROIT,MI 48201

[2] WAYNE STATE UNIV,HUTZEL HOSP,RECEIVING HOSP,DEPT PATHOL,DETROIT,MI 48201

[3] HOP NOTRE DAME DE BON SECOURS,CTR PRENATAL DIAG,PARIS,FRANCE

来源：

LANCET | 1995年 / 345卷 / 8960期

关键词：

D O I：

10.1016/S0140-6736(95)90928-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

When fetal urinary-tract malformations (UTM) are discovered, management is based on the prediction of postnatal renal function, currently made by fetal urinary biochemistry and sonography, Serum beta(2)-microglobulin has been used postnatally to estimate renal function and does not cross the placenta. We investigated the relation between fetal serum beta(2)-microglobulin and renal function by comparing 64 unaffected fetuses and 15 fetuses with UTM. A beta(2)-microglobulin above a 5.6 mg/L cut-off gave cross-validated sensitivity of 88.9%, specificity of 98.6%, a positive predictive value of 88.9%, and a negative predictive value of 97.1% for our cohort study.

引用

页码：1277 / 1278

页数：2

共 10 条

[1] BETA 2-MICROGLOBULIN CLEARANCE IN NEONATES - INDEX OF TUBULAR MATURATION [J].