FREE-RADICALS, ANTIOXIDANT ENZYMES, AND CARCINOGENESIS

被引:933
作者
SUN, Y
机构
[1] Cell Biology Section, Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick, MD
关键词
Anticarcinogenesis; Antioxidant enzymes; Antioxidants; Carcinogenesis; Free radicals; Initiation; Oxygen radicals; Promotion;
D O I
10.1016/0891-5849(90)90156-D
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Free radicals are found to be involved in both initiation and promotion of multistage carcinogenesis. These highly reactive compounds can act as initiators and/or promoters, cause DNA damage, activate procarcinogens, and alter the cellular antioxidnt defense system. Antioxidants, the free radicals scavengers, however, are shown to be anticarcinogens. They function as the inhibitors at both initiation and promotion/transformation stage of carcinogenesis and protect cells against oxidative damage. Altered antioxidant enzymes were observed during carcinogenesis or in tumors. When compared to their appropriate normal cell counterparts, tumor cells are always low in manganese superoxide dismutase activity, usually low in copper and zinc superoxide dismutase activity and almost always low in catalase activity. Glutathione peroxidase and glutathione reductase activities are highly variable. In contrast, glutathione S-transferase 7-7 is increased in many tumor cells and in chemically induced preneoplastic rat hepatocyte nodules. Increased glucose-6-phosphate dehdyrogenase activity is also found in many tumors. Comprehensive data on free radicals, antioxidant enzymes, and carcinogenesis are reviewed. The role of antioxidant enzymes in carcinogenesis is discussed. © 1990.
引用
收藏
页码:583 / 599
页数:17
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