NITROXIDERGIC INNERVATION IN DOG AND MONKEY RENAL-ARTERIES

被引:22
作者
OKAMURA, T [1 ]
YOSHIDA, K [1 ]
TODA, N [1 ]
机构
[1] SHIGA UNIV MED SCI,DEPT PHARMACOL,OTSU,SHIGA 52021,JAPAN
关键词
NITRIC OXIDE; VASODILATION; NERVOUS SYSTEM; IMMUNOHISTOCHEMISTRY; PRIMATES; RENAL ARTERY;
D O I
10.1161/01.HYP.25.5.1090
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
We analyzed mechanisms underlying neurogenic vasodilatation in dog and Japanese monkey renal arteries. Isometric mechanical responses of the arterial strip to nerve stimulation by nicotine were recorded. Nicotine-induced contractions were abolished by hexamethonium and potentiated by N-G-nitro-L-arginine, a nitric oxide synthase inhibitor. The potentiating effect was reversed by L-arginine. N-G-Nitro-L-arginine did not potentiate the contraction caused by norepinephrine. The nicotine-induced contraction was reversed to a relaxation by prazosin. The relaxation was not influenced by indomethacin, timolol, or atropine but was abolished by N-G nitro-L-arginine, methylene blue (a guanylate cyclase inhibitor), oxyhemoglobin (a nitric oxide scavenger), and hexamethonium. In the strips treated with N-G-nitro-L-arginine, the nicotine-induced relaxation was restored by L-arginine. Histochemical study demonstrated perivascular nerves containing NADPH diaphorase and nitric oxide synthase immunoreactivity in dog and monkey arteries We conclude that renal arteries are innervated by nitric oxide-mediated vasodilator and adrenergic vasoconstrictor nerves, and depression of the vasodilator nerve function by nitric oxide synthase inhibition potentiates the contraction caused by adrenergic nerve excitation.
引用
收藏
页码:1090 / 1095
页数:6
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