EFFECTS OF NG-NITRO-L-ARGININE METHYL-ESTER ON RENAL-FUNCTION AND BLOOD-PRESSURE

被引:328
作者
LAHERA, V
SALOM, MG
MIRANDAGUARDIOLA, F
MONCADA, S
ROMERO, JC
机构
[1] MAYO CLIN & MAYO FDN, MAYO SCH MED, DEPT PHYSIOL, ROCHESTER, MN 55905 USA
[2] MAYO CLIN & MAYO FDN, MAYO SCH MED, DIV HYPERTENS, ROCHESTER, MN 55905 USA
[3] WELLCOME RES LAB & WELLCOME FDN, BECKENHAM BR3 3BS, KENT, ENGLAND
来源
AMERICAN JOURNAL OF PHYSIOLOGY | 1991年 / 261卷 / 06期
关键词
ENDOTHELIUM-DERIVED RELAXING FACTOR; HYPERTENSION; RENAL EXCRETION; RENAL BLOOD FLOW; GLOMERULAR FILTRATION RATE; PRESSURE NATRIURESIS;
D O I
10.1152/ajprenal.1991.261.6.F1033
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
The dose-dependent effects of intravenous infusions of nitric oxide (NO) synthesis inhibitor, N(G)-nitro-L-arginine methyl ester (L-NAME; 0.1, 1, 10, and 50-mu-g.kg-1.min-1), were studied in anesthetized rats to determine whether the inhibitory actions of L-NAME are manifested primarily in alterations of renal function or whether they are the consequences of the increase in systemic blood pressure. Mean arterial pressure (MAP) was not altered by the intravenous L-NAME infusions of 0.1 and 1.0-mu-g.kg-1.min-1. However, 0.1-mu-g.kg-1.min-1 L-NAME induced a 30% decrease in urine flow rate (UV). The administration of 1.0-mu-g.kg-1.min-1 L-NAME, in addition to decreasing UV, also decreased urinary sodium excretion (U(Na)V) and renal plasma flow (RPF). The intravenous L-NAME infusions of 10.0 and 50.0-mu-g.kg-1.min-1 produced significant increases in MAP that reversed the initial fall in UV and U(Na)V, despite decreasing RPF and glomerular filtration rate (GFR). The administration of L-arginine alone (10-mu-g.kg-1.min-1) did not modify any of the parameters measured, but it effectively prevented all the hemodynamic and renal changes induced by the infusion of 50-mu-g.kg-1.min-1 L-NAME. These results suggest that the decrease in nitric oxide production induced by the intravenous infusion of L-NAME affects renal excretion of sodium and water in the absence of any significant change in blood pressure. At larger doses, L-NAME also produces hypertension that overrides the initial antinatriuretic effect.
引用
收藏
页码:F1033 / F1037
页数:5
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