The dose-dependent effects of intravenous infusions of nitric oxide (NO) synthesis inhibitor, N(G)-nitro-L-arginine methyl ester (L-NAME; 0.1, 1, 10, and 50-mu-g.kg-1.min-1), were studied in anesthetized rats to determine whether the inhibitory actions of L-NAME are manifested primarily in alterations of renal function or whether they are the consequences of the increase in systemic blood pressure. Mean arterial pressure (MAP) was not altered by the intravenous L-NAME infusions of 0.1 and 1.0-mu-g.kg-1.min-1. However, 0.1-mu-g.kg-1.min-1 L-NAME induced a 30% decrease in urine flow rate (UV). The administration of 1.0-mu-g.kg-1.min-1 L-NAME, in addition to decreasing UV, also decreased urinary sodium excretion (U(Na)V) and renal plasma flow (RPF). The intravenous L-NAME infusions of 10.0 and 50.0-mu-g.kg-1.min-1 produced significant increases in MAP that reversed the initial fall in UV and U(Na)V, despite decreasing RPF and glomerular filtration rate (GFR). The administration of L-arginine alone (10-mu-g.kg-1.min-1) did not modify any of the parameters measured, but it effectively prevented all the hemodynamic and renal changes induced by the infusion of 50-mu-g.kg-1.min-1 L-NAME. These results suggest that the decrease in nitric oxide production induced by the intravenous infusion of L-NAME affects renal excretion of sodium and water in the absence of any significant change in blood pressure. At larger doses, L-NAME also produces hypertension that overrides the initial antinatriuretic effect.
机构:
DARTMOUTH COLL,HITCHCOCK MED CTR,DARTMOUTH MED SCH,DEPT PHYSIOL,HANOVER,NH 03756DARTMOUTH COLL,HITCHCOCK MED CTR,DARTMOUTH MED SCH,DEPT PHYSIOL,HANOVER,NH 03756
LIGHT, DB
;
SCHWIEBERT, EM
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DARTMOUTH COLL,HITCHCOCK MED CTR,DARTMOUTH MED SCH,DEPT PHYSIOL,HANOVER,NH 03756DARTMOUTH COLL,HITCHCOCK MED CTR,DARTMOUTH MED SCH,DEPT PHYSIOL,HANOVER,NH 03756
SCHWIEBERT, EM
;
KARLSON, KH
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DARTMOUTH COLL,HITCHCOCK MED CTR,DARTMOUTH MED SCH,DEPT PHYSIOL,HANOVER,NH 03756DARTMOUTH COLL,HITCHCOCK MED CTR,DARTMOUTH MED SCH,DEPT PHYSIOL,HANOVER,NH 03756
KARLSON, KH
;
STANTON, BA
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DARTMOUTH COLL,HITCHCOCK MED CTR,DARTMOUTH MED SCH,DEPT PHYSIOL,HANOVER,NH 03756DARTMOUTH COLL,HITCHCOCK MED CTR,DARTMOUTH MED SCH,DEPT PHYSIOL,HANOVER,NH 03756
机构:
DARTMOUTH COLL,HITCHCOCK MED CTR,DARTMOUTH MED SCH,DEPT PHYSIOL,HANOVER,NH 03756DARTMOUTH COLL,HITCHCOCK MED CTR,DARTMOUTH MED SCH,DEPT PHYSIOL,HANOVER,NH 03756
LIGHT, DB
;
SCHWIEBERT, EM
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机构:
DARTMOUTH COLL,HITCHCOCK MED CTR,DARTMOUTH MED SCH,DEPT PHYSIOL,HANOVER,NH 03756DARTMOUTH COLL,HITCHCOCK MED CTR,DARTMOUTH MED SCH,DEPT PHYSIOL,HANOVER,NH 03756
SCHWIEBERT, EM
;
KARLSON, KH
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DARTMOUTH COLL,HITCHCOCK MED CTR,DARTMOUTH MED SCH,DEPT PHYSIOL,HANOVER,NH 03756DARTMOUTH COLL,HITCHCOCK MED CTR,DARTMOUTH MED SCH,DEPT PHYSIOL,HANOVER,NH 03756
KARLSON, KH
;
STANTON, BA
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机构:
DARTMOUTH COLL,HITCHCOCK MED CTR,DARTMOUTH MED SCH,DEPT PHYSIOL,HANOVER,NH 03756DARTMOUTH COLL,HITCHCOCK MED CTR,DARTMOUTH MED SCH,DEPT PHYSIOL,HANOVER,NH 03756