FUSION OF THE DOMINANT-NEGATIVE TRANSCRIPTION REGULATOR CHOP WITH A NOVEL GENE FUS BY TRANSLOCATION T(12-16) IN MALIGNANT LIPOSARCOMA

被引:495
作者
RABBITTS, TH
FORSTER, A
LARSON, R
NATHAN, P
机构
[1] MRC Laboratory of Molecular Biology, Cambridge, CB2 2QH, Hills Road
关键词
D O I
10.1038/ng0693-175
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The search for tumour-specific markers is one of the chief goals in cancer biology. We show that the translocation t(12;16)(q13:p11) in malignant myxoid liposarcoma can be a fusion of the CHOP dominant negative transcription factor gene with a novel gene, FUS, which can result in fusion of the FUS glycine-rich protein with the whole CHOP coding region. The data support the concept that protein fusion may commonly occur in solid tumours resulting in tumour-specific markers of potential clinical importance. The data also indicate the importance of transcription disruption in the pathogenesis of solid tumours.
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页码:175 / 180
页数:6
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