INHIBITION OF HEPATITIS-B VIRUS IN TISSUE-CULTURE BY ALPHA-INTERFERON

被引：16

作者：

DAVIS, MG ^{[1
]}

JANSEN, RW ^{[1
]}

机构：

[1] BURROUGHS WELLCOME CO,DIV EXPTL THERAPY,RES TRIANGLE PK,NC 27709

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1994年 / 38卷 / 12期

关键词：

D O I：

10.1128/AAC.38.12.2921

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Alpha-nl interferon (Wellferon), alpha-2a interferon (Roferon), and alpha 2b interferon (Intron-A) inhibited accumulation of intracellular replicative forms of hepatitis B virus (HBV) in chronic producer cells by inhibiting accumulation of RNase-resistant HBV RNA. In contrast, the nucleoside analog PTC (cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine) inhibited the accumulation of HBV DNA.

引用

页码：2921 / 2924

页数：4

共 14 条

[11] PRODUCTION OF HEPATITIS-B VIRUS-PARTICLES IN HEP-G2 CELLS TRANSFECTED WITH CLONED HEPATITIS-B VIRUS-DNA
SELLS, MA
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[12] Staeheli P, 1990, Adv Virus Res, V38, P147, DOI 10.1016/S0065-3527(08)60862-3
[13] STABLE EXPRESSION AND REPLICATION OF HEPATITIS-B VIRUS GENOME IN AN INTEGRATED STATE IN A HUMAN HEPATOMA-CELL LINE TRANSFECTED WITH THE CLONED VIRAL-DNA
TSURIMOTO, T
FUJIYAMA, A
MATSUBARA, K
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (02) : 444 - 448
[14] VALENZUELA P, 1980, ANIMAL VIRUS GENETIC, P57

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