EFFECT OF AGING AND ACETYL-L-CARNITINE ON THE ACTIVITY OF CYTOCHROME-OXIDASE AND ADENINE-NUCLEOTIDE TRANSLOCASE IN RAT-HEART MITOCHONDRIA

被引：89

作者：

PARADIES, G ^{[1
]}

RUGGIERO, FM ^{[1
]}

PETROSILLO, G ^{[1
]}

GADALETA, MN ^{[1
]}

QUAGLIARIELLO, E ^{[1
]}

机构：

[1] UNIV BARI,CNR,STUDY MITOCHONDRIA & BIOENERGET UNIT,BARI,ITALY

来源：

FEBS LETTERS | 1994年 / 350卷 / 2-3期

关键词：

CYTOCHROME OXIDASE; ADP TRANSLOCASE; AGING; ACETYL-L-CARNITINE; RAT HEART MITOCHONDRIA;

D O I：

10.1016/0014-5793(94)00763-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of aging and treatment with acetyl-L-carnitine on the activity of cytochrome oxidase and adenine nucleotide translocase in rat heart mitochondria was studied. It was found that the activity of both these mitochondrial protein systems was reduced (by around 30%) in aged animals. Treatment of aged rats with acetyl-L-carnitine almost completely reversed this effect. Changes in the mitochondrial cardiolipin content appear to be responsible for these effects of acetyl-L-carnitine.

引用

页码：213 / 215

页数：3