TEMPERATURE-DEPENDENT EXPRESSION OF MEASLES-VIRUS STRUCTURAL PROTEINS IN PERSISTENTLY INFECTED-CELLS

被引：11

作者：

FISHER, LE ^{[1
]}

RAPP, F ^{[1
]}

机构：

[1] PENN STATE UNIV,MILTON S HERSHEY MED CTR,COLL MED,DEPT MICROBIOL,HERSHEY,PA 17033

来源：

VIROLOGY | 1979年 / 94卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0042-6822(79)90437-9

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Hamster embryo fibroblasts persistently infected with measles virus (S cells) spontaneously release infectious virus at 33.5° but little infectious virus is released from the cells at 39.5°. Virus released from the cells is not temperature sensitive. Analysis of membrane-free cytoplasmic supernates and membrane fractions from S cells shows that differences exist in the expression of virus structural proteins at the permissive and nonpermissive temperatures. The expression of viral proteins in persistently infected cells grown at either 33.5 or 39.5° differs from that in lytically infected cells. Such differential expression of structural proteins may function in the maintenance of persistent measles infection in S cells. © 1979.

引用

页码：55 / 60

页数：6

共 17 条

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