EFFECT OF THE EBNA-2 GENE ON THE SURFACE-ANTIGEN PHENOTYPE OF TRANSFECTED EBV-NEGATIVE B-LYMPHOMA LINES

被引：26

作者：

AMAN, P

ROWE, M

KAI, C

FINKE, J

RYMO, L

KLEIN, E

KLEIN, G

机构：

[1] KAROLINSKA INST,DEPT TUMOR BIOL,S-10401 STOCKHOLM 60,SWEDEN

[2] GOTHENBURG UNIV,DEPT MED BIOCHEM,S-40033 GOTHENBURG,SWEDEN

来源：

INTERNATIONAL JOURNAL OF CANCER | 1990年 / 45卷 / 01期

关键词：

D O I：

10.1002/ijc.2910450115

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Two EBV‐negative B‐lymphoma cell lines with different phenotypes were transfected with the Epstein‐Barr virus EBNA‐2 gene. The effects on the expression of 8 B‐cell surface markers were analyzed by immunofluorescence methods. In one of the EBNA‐2 transfected cell lines, the expression of the CR2 receptor CD21 was induced and the expression of CD23 was enhanced. The results suggest that the EBNA‐2 gene is involved in the regulation of CD21 and CD23 in EBV‐carrying cells. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company

引用

页码：77 / 82

页数：6

共 42 条

[1] EPSTEIN-BARR VIRUS SUSCEPTIBILITY OF NORMAL HUMAN B-LYMPHOCYTE POPULATIONS
AMAN, P
EHLINHENRIKSSON, B
KLEIN, G
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1984, 159 (01) : 208 - 220
[2] AMAN P, 1985, J IMMUNOL, V135, P1154
[3] PRODUCTION BY EBV INFECTION OF AN EBNA-POSITIVE SUBLINE FROM AN EBNA-NEGATIVE HUMAN LYMPHOMA CELL LINE WITHOUT DETECTABLE EBV DNA
CLEMENTS, GB
KLEIN, G
POVEY, S
[J]. INTERNATIONAL JOURNAL OF CANCER, 1975, 16 (01) : 125 - 133
[4] ANTIBODIES AGAINST A SYNTHETIC PEPTIDE IDENTIFY THE EPSTEIN-BARR VIRUS-DETERMINED NUCLEAR ANTIGEN
DILLNER, J
STERNAS, L
KALLIN, B
ALEXANDER, H
EHLINHENRIKSSON, B
JORNVALL, H
KLEIN, G
LERNER, R
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (15): : 4652 - 4656
[5] THE EPSTEIN-BARR VIRUS PROTEINS
DILLNER, J
KALLIN, B
[J]. ADVANCES IN CANCER RESEARCH, 1988, 50 : 95 - 158
[6] MONOCLONAL AND POLYCLONAL ANTIBODIES AGAINST EPSTEIN-BARR-VIRUS NUCLEAR ANTIGEN-5 (EBNA-5) DETECT MULTIPLE PROTEIN SPECIES IN BURKITTS-LYMPHOMA AND LYMPHOBLASTOID CELL-LINES
FINKE, J
ROWE, M
KALLIN, B
ERNBERG, I
ROSEN, A
DILLNER, J
KLEIN, G
[J]. JOURNAL OF VIROLOGY, 1987, 61 (12) : 3870 - 3878
[7] GP140, THE C3D RECEPTOR OF HUMAN LYMPHOCYTES-B, IS ALSO THE EPSTEIN-BARR VIRUS RECEPTOR
FRADE, R
BAREL, M
EHLINHENRIKSSON, B
KLEIN, G
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (05) : 1490 - 1493
[8] THE MOLECULES CONTROLLING LYMPHOCYTES-B
GORDON, J
GUY, GR
[J]. IMMUNOLOGY TODAY, 1987, 8 (11): : 339 - 344
[9] GORDON J, 1983, BLOOD, V62, P910
[10] A 2ND NUCLEAR-PROTEIN IS ENCODED BY EPSTEIN-BARR VIRUS IN LATENT INFECTION
HENNESSY, K
KIEFF, E
[J]. SCIENCE, 1985, 227 (4691) : 1238 - 1240

← 1 2 3 4 5 →