EFFECT OF THE EBNA-2 GENE ON THE SURFACE-ANTIGEN PHENOTYPE OF TRANSFECTED EBV-NEGATIVE B-LYMPHOMA LINES

被引：26

作者：

AMAN, P

ROWE, M

KAI, C

FINKE, J

RYMO, L

KLEIN, E

KLEIN, G

机构：

[1] KAROLINSKA INST,DEPT TUMOR BIOL,S-10401 STOCKHOLM 60,SWEDEN

[2] GOTHENBURG UNIV,DEPT MED BIOCHEM,S-40033 GOTHENBURG,SWEDEN

来源：

INTERNATIONAL JOURNAL OF CANCER | 1990年 / 45卷 / 01期

关键词：

D O I：

10.1002/ijc.2910450115

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Two EBV‐negative B‐lymphoma cell lines with different phenotypes were transfected with the Epstein‐Barr virus EBNA‐2 gene. The effects on the expression of 8 B‐cell surface markers were analyzed by immunofluorescence methods. In one of the EBNA‐2 transfected cell lines, the expression of the CR2 receptor CD21 was induced and the expression of CD23 was enhanced. The results suggest that the EBNA‐2 gene is involved in the regulation of CD21 and CD23 in EBV‐carrying cells. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company

引用

页码：77 / 82

页数：6

共 42 条

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