ELEVATED LEVELS OF PDGF-ALPHA RECEPTORS IN KELOID FIBROBLASTS CONTRIBUTE TO AN ENHANCED RESPONSE TO PDGF

被引：105

作者：

HAISA, M ^{[1
]}

OKOCHI, H ^{[1
]}

GROTENDORST, GR ^{[1
]}

机构：

[1] UNIV MIAMI,SCH MED,DEPT CELL BIOL & ANAT R-124,MIAMI,FL 33136

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 1994年 / 103卷 / 04期

关键词：

PLATELET-DERIVED GROWTH FACTOR; EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR;

D O I：

10.1111/1523-1747.ep12396856

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Despite a number of studies, the etiology of keloids remains unknown. We have investigated the response of fibroblasts derived from keloid tissue and normal adult skin to platelet-derived growth factor (PDGF), epidermal growth factor (EGF), and fibroblast growth factor (FGF). Keloid fibroblasts were more responsive in both chemotactic and mitogenic assays to all three isoforms of PDGF than fibroblasts from normal skin. No enhanced response of the cells to either EGF or FGF was detected. The enhanced PDGF response of keloid fibroblasts appears to be mediated by elevated levels of PDGF alpha receptors, which are 4-5 times higher than those in normal human skin fibroblasts.

引用

页码：560 / 563

页数：4

共 40 条

[11] CLONING AND EXPRESSION OF A CDNA CODING FOR THE HUMAN PLATELET-DERIVED GROWTH-FACTOR RECEPTOR - EVIDENCE FOR MORE THAN ONE RECEPTOR CLASS
GRONWALD, RGK
GRANT, FJ
HALDEMAN, BA
HART, CE
OHARA, PJ
HAGEN, FS
ROSS, R
BOWENPOPE, DF
MURRAY, MJ
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (10) : 3435 - 3439
[12] ATTACHMENT OF SMOOTH-MUSCLE CELLS TO COLLAGEN AND THEIR MIGRATION TOWARD PLATELET-DERIVED GROWTH-FACTOR
GROTENDORST, GR
SEPPA, HEJ
KLEINMAN, HK
MARTIN, GR
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (06): : 3669 - 3672
[13] DIFFERENTIAL BINDING, BIOLOGICAL AND BIOCHEMICAL ACTIONS OF RECOMBINANT PDGF AA, AB, AND BB MOLECULES ON CONNECTIVE-TISSUE CELLS
GROTENDORST, GR
IGARASHI, A
LARSON, R
SOMA, Y
CHARETTE, M
[J]. JOURNAL OF CELLULAR PHYSIOLOGY, 1991, 149 (02) : 235 - 243
[14] ALTERATION OF THE CHEMOTACTIC RESPONSE OF NIH/3T3 CELLS TO PDGF BY GROWTH-FACTORS, TRANSFORMATION, AND TUMOR PROMOTERS
GROTENDORST, GR
[J]. CELL, 1984, 36 (02) : 279 - 285
[15] GROTENDORST GR, 1982, METHOD ENZYMOL, V147, P144
[16] GROTENDORST GR, MOL MEDIATORS TISSUE, P20
[17] EFFECT OF GROWTH-FACTORS ON HYALURONAN SYNTHESIS IN CULTURED HUMAN-FIBROBLASTS
HELDIN, P
LAURENT, TC
HELDIN, CH
[J]. BIOCHEMICAL JOURNAL, 1989, 258 (03) : 919 - 922
[18] ENZYME ACTIVITIES IN HYPERTROPHIC SCARS AND KELOIDS
HOOPES, JE
SU, CT
IM, MJC
[J]. PLASTIC AND RECONSTRUCTIVE SURGERY, 1971, 47 (02) : 132 - +
[19] INUI H, 1993, J BIOL CHEM, V268, P17045
[20] THE ULTRASTRUCTURE OF A KELOID
JAMES, WD
BESANCENEY, CD
ODOM, RB
[J]. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1980, 3 (01) : 50 - 57

← 1 2 3 4 →