ORGANIZATION OF THE GENE FOR ISO-RANP, A RAT B-TYPE NATRIURETIC PEPTIDE

被引：26

作者：

ROY, RN ^{[1
]}

FLYNN, TG ^{[1
]}

机构：

[1] QUEENS UNIV,DEPT BIOCHEM,KINGSTON K7L 3N6,ONTARIO,CANADA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 171卷 / 01期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0006-291X(90)91409-L

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Using the polymerase chain reaction and oligonucleotide primers constructed from knowledge of the cDNA sequence we have sequenced the gene for iso-rANP, a peptide of the B-type of atrial natriuretic peptides. The overall organization of the rat iso-ANP gene is the same as that of ANP and BNP consisting of three exons and two introns at relatively similar positions. Iso-rANP and it's gene are more closely related to BNPs than ANP and yet there are significant differences at both the protein and DNA levels. Our results suggest that iso-rANP and BNP are distinct members of the same sub-family (B-type natriuretic peptides) within the family of natriuretic peptide genes. © 1990.

引用

页码：416 / 423

页数：8

共 23 条

[1] ISOLATION AND IDENTIFICATION OF RAT-BRAIN NATRIURETIC PEPTIDES IN CARDIAC ATRIUM [J].

ABURAYA, M ;

HINO, J ;

MINAMINO, N ;

KANGAWA, K ;

MATSUO, H .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 163 (01) :226-232

[2]

ARGENTIN S, 1985, J BIOL CHEM, V260, P4568

[3]

CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1016/0003-2697(87)90021-2

[4] A COMPREHENSIVE SET OF SEQUENCE-ANALYSIS PROGRAMS FOR THE VAX [J].

DEVEREUX, J ;

HAEBERLI, P ;

SMITHIES, O .

NUCLEIC ACIDS RESEARCH, 1984, 12 (01) :387-395

[5]

FLYNN TG, 1989, BIOCHEM BIOPH RES CO, V163, P1189

[6] ISOLATION AND CHARACTERIZATION OF ISO-RANP, A NEW NATRIURETIC PEPTIDE FROM RAT ATRIA [J].

FLYNN, TG ;

BRAR, A ;

TREMBLAY, L ;

SARDA, I ;

LYONS, C ;

JENNINGS, DB .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 161 (02) :830-837

[7] NUCLEOTIDE-SEQUENCE OF THE GENE ENCODING HUMAN ATRIAL NATRIURETIC FACTOR PRECURSOR [J].

GREENBERG, BD ;

BENCEN, GH ;

SEILHAMER, JJ ;

LEWICKI, JA ;

FIDDES, JC .

NATURE, 1984, 312 (5995) :656-658

[8] A SIMPLE AND VERY EFFICIENT METHOD FOR GENERATING CDNA LIBRARIES [J].

GUBLER, U ;

HOFFMAN, BJ .

GENE, 1983, 25 (2-3) :263-269

[9]

INAGAMI T, 1989, J BIOL CHEM, V264, P3043

[10] ISOLATION AND SEQUENCE DETERMINATION OF RAT CARDIAC NATRIURETIC PEPTIDE [J].

KAMBAYASHI, Y ;

NAKAO, K ;

ITOH, H ;

HOSODA, K ;

SAITO, Y ;

YAMADA, T ;

MUKOYAMA, M ;

ARAI, H ;

SHIRAKAMI, G ;

SUGA, SI ;

OGAWA, Y ;

JOUGASAKI, M ;

MINAMINO, N ;

KANGAWA, K ;

MATSUO, H ;

INOUYE, K ;

IMURA, H .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 163 (01) :233-240

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