ORGANIZATION OF THE GENE FOR ISO-RANP, A RAT B-TYPE NATRIURETIC PEPTIDE

被引：26

作者：

ROY, RN ^{[1
]}

FLYNN, TG ^{[1
]}

机构：

[1] QUEENS UNIV,DEPT BIOCHEM,KINGSTON K7L 3N6,ONTARIO,CANADA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 171卷 / 01期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0006-291X(90)91409-L

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Using the polymerase chain reaction and oligonucleotide primers constructed from knowledge of the cDNA sequence we have sequenced the gene for iso-rANP, a peptide of the B-type of atrial natriuretic peptides. The overall organization of the rat iso-ANP gene is the same as that of ANP and BNP consisting of three exons and two introns at relatively similar positions. Iso-rANP and it's gene are more closely related to BNPs than ANP and yet there are significant differences at both the protein and DNA levels. Our results suggest that iso-rANP and BNP are distinct members of the same sub-family (B-type natriuretic peptides) within the family of natriuretic peptide genes. © 1990.

引用

页码：416 / 423

页数：8

共 23 条

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