COMPARATIVE EFFICACIES OF TICARCILLIN, TICARCILLIN CLAVULANIC ACID, PIPERACILLIN AND CEFOXITIN AGAINST POLYMICROBIAL INFECTIONS IN MICE CAUSED BY ESCHERICHIA-COLI AND BACTEROIDES-FRAGILIS

被引:2
作者
BEALE, AS
GISBY, J
机构
[1] Smith Kline Beecham Pharmaceuticals, Betchworth, RH3 7AJ, Surrey, Brockham Park
关键词
D O I
10.1007/BF01645577
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
A model of localised abscess formation was used to establish mixed infections caused by Escherichia coli and Bacteroides fragilis. The beta-lactamase producing, ticarcillin-resistant strains E. coli E96 and B. fragilis VPI 8708 were used to produce one infection, and in another infection, a beta-lactamase hyperproducing strain E. coli 41548 was combined with a ticarcillin-susceptible strain, B. fragilis B3. Treatment, at doses producing clinically achievable concentrations in mouse serum, began 1 h after inoculation, and continued three times daily for four days. Bacterial numbers in infected tissue were measured at intervals. Against both infections, ticarcillin was ineffective in preventing bacterial growth and abscess formation in all mice. Piperacillin prevented abscess formation in 60% of the mice infected with E. coli E96/B. fragilis VPI 8708, and in 40% of those in the E. coli 41548/B. fragilis B3 group. Therapy with ticarcillin/clavulanic acid or cefoxitin reduced the number of both organisms at the site of infection, and thus prevented abscess formation in 100% treated animals.
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页码:101 / 105
页数:5
相关论文
共 17 条
[11]   A COMPARISON OF INTRAVENOUS CEFOXITIN AND A COMBINATION OF GENTAMICIN AND METRONIDAZOLE AS PROPHYLAXIS IN COLORECTAL SURGERY [J].
MCDONALD, PJ ;
KARRAN, SJ .
DISEASES OF THE COLON & RECTUM, 1983, 26 (10) :661-664
[12]  
SCHROGIE JJ, 1978, J ANTIMICROB CHEM SB, V4
[13]   PHARMACOLOGY OF TICARCILLIN COMBINED WITH CLAVULANIC ACID IN HUMANS [J].
SCULLY, BE ;
CHIN, NX ;
NEU, HC .
AMERICAN JOURNAL OF MEDICINE, 1985, 79 (5B) :39-43
[14]   ANTIBACTERIAL ACTIVITY OF TICARCILLIN IN THE PRESENCE OF CLAVULANATE POTASSIUM [J].
SUTHERLAND, R ;
BEALE, AS ;
BOON, RJ ;
GRIFFIN, KE ;
SLOCOMBE, B ;
STOKES, DH ;
WHITE, AR .
AMERICAN JOURNAL OF MEDICINE, 1985, 79 (5B) :13-24
[15]  
TEHAN S, 1988, BRIT J CLIN PRACT, V42, P8
[16]   CORRELATION OF ANTIMICROBIAL PHARMACOKINETIC PARAMETERS WITH THERAPEUTIC EFFICACY IN AN ANIMAL-MODEL [J].
VOGELMAN, B ;
GUDMUNDSSON, S ;
LEGGETT, J ;
TURNIDGE, J ;
EBERT, S ;
CRAIG, WA .
JOURNAL OF INFECTIOUS DISEASES, 1988, 158 (04) :831-847
[17]   CHEMOTHERAPY OF AN EXPERIMENTAL BACTEROIDES-FRAGILIS INFECTION IN MICE [J].
WALKER, CB ;
NITZAN, D ;
WILKINS, TD .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1977, 11 (03) :435-440