DETERMINATION OF RATE DISTRIBUTIONS FROM KINETIC-EXPERIMENTS

被引：101

作者：

STEINBACH, PJ ^{[1
]}

CHU, K ^{[1
]}

FRAUENFELDER, H ^{[1
]}

JOHNSON, JB ^{[1
]}

LAMB, DC ^{[1
]}

NIENHAUS, GU ^{[1
]}

SAUKE, TB ^{[1
]}

YOUNG, RD ^{[1
]}

机构：

[1] UNIV ILLINOIS,DEPT PHYS,URBANA,IL 61801

来源：

BIOPHYSICAL JOURNAL | 1992年 / 61卷 / 01期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

D O I：

10.1016/S0006-3495(92)81830-1

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Rate processes in proteins are often not adequately described by simple exponential kinetics. Instead of modeling the kinetics in the time domain, it can be advantageous to perform a numerical inversion leading to a rate distribution function f(lambda). The features observed in f(lambda) (number, positions, and shapes of peaks) can then be interpreted. We discuss different numerical techniques for obtaining rate distribution functions, with special emphasis on the maximum entropy method. Examples are given for the application of these techniques to flash photolysis data of heme proteins.

引用

收藏

页码：235 / 245

页数：11

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