Curcumin modulates cellular AP-1, NF-kB, and HPV16 E6 proteins in oral cancer

被引：76

作者：

Mishra, Alok ^{[1
,2
,3
]}

Kumar, Rakesh ^{[1
,2
,4
]}

Tyagi, Abhishek ^{[1
,2
]}

Kohaar, Indu ^{[1
,3
]}

Hedau, Suresh ^{[1
]}

Bharti, Alok C. ^{[1
]}

Sarker, Subhodeep ^{[1
]}

Dey, Dipankar ^{[1
]}

Saluja, Daman ^{[2
]}

Das, Bhudev ^{[1
,2
,5
]}

机构：

[1] Inst Cytol & Prevent Oncol ICMR, 1-7,Sect 39, Noida 201301, India

[2] Univ Delhi, ACBR, Delhi 110007, India

[3] NCI, NIH, Bethesda, MD 20892 USA

[4] Mayo Clin, Rochester, MN 55905 USA

[5] Amity Univ, Noida 201303, India

来源：

ECANCERMEDICALSCIENCE | 2015年 / 9卷

关键词：

activator protein-1 (AP-1); curcumin; human papilloma virus (HPA); nuclear factor kappaB (NF-kB); transcription;

D O I：

10.3332/ecancer.2015.525

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

In this study, we investigated the effects of the natural antioxidant curcumin on the HPV16-positive oral carcinoma cell line 93VU147T and demonstrated that curcumin is not only a potent inhibitor for the activity of host nuclear transcription factors AP-1 and NF-kB but it also selectively suppresses transcription of the HPV16/E6 oncogene during the carcinogenic process in oral cancer cells. This study suggests a therapeutic potential of curcumin for high-risk human papilloma virus (HPV)-infected oral cancers.

引用

页数：12

共 36 条

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