SYNTHESIS OF A FULLERENE DERIVATIVE FOR THE INHIBITION OF HIV ENZYMES

被引：474

作者：

SIJBESMA, R

SRDANOV, G

WUDL, F

CASTORO, JA

WILKINS, C

FRIEDMAN, SH

DECAMP, DL

KENYON, GL

机构：

[1] UNIV CALIF SANTA BARBARA,INST POLYMERS & ORGAN SOLIDS,DEPT CHEM & PHYS,SANTA BARBARA,CA 93106

[2] UNIV CALIF RIVERSIDE,DEPT CHEM,RIVERSIDE,CA 92521

[3] UNIV CALIF SAN FRANCISCO,DEPT PHARMACEUT CHEM,SAN FRANCISCO,CA 94143

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1993年 / 115卷 / 15期

关键词：

D O I：

10.1021/ja00068a006

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A diamido diacid diphenyl fulleroid derivative (2c) was designed specifically to inhibit an HIV enzyme. The detailed synthesis and mass spectrometric analysis of the water-soluble, biologically active methanofullerene are described. The compound was prepared in three steps from C60 via a suitably substituted diphenyldiazomethane. High-resolution mass spectrometric analysis was possible only under mild matrix-assisted laser desorption/ionization Fourier transform mass spectrometry conditions. Direct infrared or ultraviolet laser desorption resulted exclusively in observation of C60 ions, in either positive or negative mode.

引用

页码：6510 / 6512

页数：3

共 20 条

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