XANTHINE-OXIDASE ACTIVATION IN CERULEIN-INDUCED AND TAUROCHOLATE-INDUCED ACUTE-PANCREATITIS IN RATS

被引：26

作者：

CLOSA, D ^{[1
]}

BULBENA, O ^{[1
]}

HOTTER, G ^{[1
]}

ROSELLOCATAFAU, J ^{[1
]}

FERNANDEZCRUZ, L ^{[1
]}

GELPI, E ^{[1
]}

机构：

[1] HOSP CLIN BARCELONA,DEPT SURG,BARCELONA,SPAIN

来源：

ARCHIVES INTERNATIONALES DE PHYSIOLOGIE DE BIOCHIMIE ET DE BIOPHYSIQUE | 1994年 / 102卷 / 03期

关键词：

PANCREATITIS; TAUROCHOLATE; CERULEIN; OXYGEN FREE RADICAL; XANTHINE OXIDASE; RAT;

D O I：

10.3109/13813459409007532

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Oxygen free radicals (OFR) are postulated to play a role in the pathogenesis of acute pancreatitis. The aim of this work was to examine the role of xanthine oxidase in the generation of OFR and the activity of the endogenous defense mechanisms as reflected by pancreatic superoxide dismutase (SOD) activity in a model of edematous pancreatitis induced in rats by administration of cerulein at supramaximal doses, as well as in necrohemorrhagic model induced by intraductal administration of sodium taurocholate. Comparison between these two models of pancreatitis suggests important differences in origin and importance in the evolution of injury. In necrohemorrhagic pancreatitis OFR can be produced by xanthine oxidase activity probably associated to cell death. By contrast, in cerulein induced pancreatitis, other sources of oxygen free radicals, such as inflammatory cells, can be of more importance.

引用

页码：167 / 170

页数：4

共 25 条

[21]

STIRPE F, 1969, J BIOL CHEM, V244, P3855

[22]

SUN Y, 1988, CLIN CHEM, V34, P497

[23] A NEW ROLE FOR PHOSPHOLIPASE-A2 - PROTECTION OF MEMBRANES FROM LIPID-PEROXIDATION DAMAGE [J].

VANKUIJK, FJGM ;

SEVANIAN, A ;

HANDELMAN, GJ ;

DRATZ, EA .

TRENDS IN BIOCHEMICAL SCIENCES, 1987, 12 (01) :31-34

[24]

WILLEMER S, 1991, INT J PANCREATOL, V9, P21

[25]

YAMANAKA N, 1979, PHYSIOL CHEM PHYS M, V11, P253

← 1 2 3 →