MOST EFFICIENT INTRAMOLECULAR GENERAL ACID CATALYSIS OF ACETAL HYDROLYSIS BY THE CARBOXY GROUP

被引：35

作者：

KIRBY, AJ

PARKINSON, A

机构：

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1994年 / 06期

关键词：

D O I：

10.1039/c39940000707

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The hydrolysis of 4-methoxymethoxybenzisoxazole-3-carboxylic acid (halflife 31 s at 39-degrees-C) is the fastest measured for a methoxymethyl acetal: catalysis by the neighbouring CO2H group is facilitated by a strong intramolecular hydrogen bond.

引用

页码：707 / 708

页数：2

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