SUSTAINED ISOMETRIC CONTRACTION OF SKELETAL-MUSCLE RESULTS IN RELEASE OF IMMUNOREACTIVE NEUROKININS IN THE SPINAL-CORD OF THE ANESTHETIZED CAT

被引：30

作者：

DUGGAN, AW ^{[1
]}

HOPE, PJ ^{[1
]}

LANG, CW ^{[1
]}

WILLIAMS, CA ^{[1
]}

机构：

[1] E TENNESSEE STATE UNIV,QUILLEN DISHNER COLL MED,DEPT PHYSIOL,JOHNSON CITY,TN 37614

来源：

NEUROSCIENCE LETTERS | 1991年 / 122卷 / 02期

基金：

英国惠康基金;

关键词：

ISOMETRIC MUSCLE CONTRACTION; NEUROKININ RELEASE; SPINAL CORD; ANTIBODY MICROPROBE;

D O I：

10.1016/0304-3940(91)90855-N

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Antibody microprobes were used to study release of immunoreactive neurokinins in the dorsal horn of the anaesthetized spinal cat following sustained isometric contraction of ipsilateral hindlimb muscles. Microprobes had immobilized antibodies to neurokinin A (NKA) on their outer surfaces and bound a proportion of released molecules when inserted in the central nervous system. Bound molecules were detected in autoradiographs as zones of reduced binding of I-125-NKA in which microprobes were incubated after withdrawal from the spinal cord. The left hindlimb was immobilized using an epoxy bandage splint isometric contraction of muscles induced by intermittent tetanic stimulation of a ventral root. A basal presence of immunoreactive neurokinins was detected and this was increased by sustained isometric muscle contraction. It is probable that ergoreceptors contain and release neurokinins.

引用

页码：191 / 194

页数：4

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