PERFORIN-MEDIATED MYOCARDIAL DAMAGE IN ACUTE MYOCARDITIS

被引：74

作者：

YOUNG, LHY

JOAG, SV

ZHENG, LM

LEE, CP

LEE, YS

YOUNG, JDE

机构：

[1] ROCKEFELLER UNIV,NEW YORK,NY 10021

[2] HARVARD UNIV,MASSACHUSETTS EYE & EAR INFIRM,SCH MED,BOSTON,MA 02114

[3] CHANG GUNG MEM HOSP,TAIPEI,TAIWAN

来源：

LANCET | 1990年 / 336卷 / 8722期

关键词：

D O I：

10.1016/0140-6736(90)92486-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Endomyocardial specimens were obtained from 7 patients with acute myocarditis. Immunohistochemical examination of the mononuclear infiltrate showed mainly cytotoxic T lymphocytes and natural killer cells. Perforin (a pore-forming protein found in cytotoxic lymphocytes) was identified in this myocardial lymphocytic infiltrate and electron microscopy showed myocardial cell damage that may have been associated with these perforin containing lymphocytes. The results indicate that in acute idiopathic and viral myocarditis, myocardial damage may be due to the action of perforin-secretinq lymphocytes. © 1990.

引用

页码：1019 / 1021

页数：3

共 13 条

[11] CELLULAR AND HUMORAL MECHANISMS OF CYTO-TOXICITY - STRUCTURAL AND FUNCTIONAL ANALOGIES [J].