TOXICITY OF AMPHOTERICIN-B EMULSION TO CULTURED CANINE KIDNEY-CELL MONOLAYERS

被引：13

作者：

LAMB, KA ^{[1
]}

WASHINGTON, C ^{[1
]}

DAVIS, SS ^{[1
]}

DENYER, SP ^{[1
]}

机构：

[1] UNIV NOTTINGHAM, DEPT PHARMACEUT SCI, UNIV PK, NOTTINGHAM NG7 2RD, ENGLAND

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1991年 / 43卷 / 07期

关键词：

D O I：

10.1111/j.2042-7158.1991.tb03529.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effect of amphotericin B in an emulsion formulation on the integrity of monolayers of kidney cells has been studied. Whereas a conventional solubilized amphotericin formulation (Fungizone, Squibb) caused a loss in monolayer integrity at concentrations above 1-mu-g mL-1, the emulsion formulation had no measurable effect on confluence at amphotericin concentrations up to 100-mu-g mL-1. The emulsion retained a comparable antifungal activity to that of Fungizone against Saccharomyces cerevisiae in suspension culture. These results parallel the observed erythrocyte lysis data obtained previously using amphotericin B emulsions, and suggest that the emulsion formulation may have a lower toxicity and improved therapeutic potential over existing formulations.

引用

页码：522 / 524

页数：3

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