A CHILD WITH VALPROIC ACID - ASSOCIATED CARNITINE DEFICIENCY AND CARNITINE-RESPONSIVE CARDIAC DYSFUNCTION

被引：11

作者：

BRATTON, SL

GARDEN, AL

BOHAN, TP

FRENCH, JW

CLARKE, WR

机构：

[1] UNIV WASHINGTON,DEPT ANESTHESIOL,SEATTLE,WA 98195

[2] UNIV WASHINGTON,DEPT PEDIAT,SEATTLE,WA 98195

[3] AUCKLAND HOSP,AUCKLAND 3,NEW ZEALAND

[4] UNIV TEXAS,SCH MED,DEPT NEUROL,HOUSTON,TX 77025

[5] UNIV TEXAS,SCH MED,DEPT PEDIAT,HOUSTON,TX 77025

[6] UNIV TEXAS,SCH MED,DEPT PHARMACOL,HOUSTON,TX 77025

来源：

JOURNAL OF CHILD NEUROLOGY | 1992年 / 7卷 / 04期

关键词：

D O I：

10.1177/088307389200700416

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Valproic acid enhances renal losses of carnitine esters and leads to decreased plasma free carnitine concentrations in many patients receiving valproic acid therapy. However, decreased serum carnitine levels are of unclear pathologic significance, and most children manifest no symptoms of carnitine deficiency. We report a child with valproic acid-associated carnitine deficiency who had severe cardiac dysfunction develop that resolved with carnitine replacement therapy.

引用

页码：413 / 416

页数：4

共 19 条

[11] CARNITINE DEFICIENCY ASSOCIATED WITH ANTICONVULSANT THERAPY [J].

RODRIGUEZSEGADE, S ;

DELAPENA, CA ;

TUTOR, JC ;

PAZ, JM ;

FERNANDEZ, MP ;

ROZAS, I ;

DELRIO, R .

CLINICA CHIMICA ACTA, 1989, 181 (02) :175-181

[12] MUSCLE CARNITINE DEFICIENCY IN PATIENTS USING VALPROIC ACID [J].

SHAPIRA, Y ;

GUTMAN, A .

JOURNAL OF PEDIATRICS, 1991, 118 (04) :646-649

[13]

Stanley C A, 1987, Adv Pediatr, V34, P59

[14] IMPAIRED SKIN FIBROBLAST CARNITINE UPTAKE IN PRIMARY SYSTEMIC CARNITINE DEFICIENCY MANIFESTED BY CHILDHOOD CARNITINE-RESPONSIVE CARDIOMYOPATHY [J].

TEIN, I ;

DEVIVO, DC ;

BIERMAN, F ;

PULVER, P ;

DEMEIRLEIR, LJ ;

CVITANOVICSOJAT, L ;

PAGON, RA ;

BERTINI, E ;

DIONISIVICI, C ;

SERVIDEI, S ;

DIMAURO, S .

PEDIATRIC RESEARCH, 1990, 28 (03) :247-255

[15] VALPROATE-INDUCED COMA WITH KETOSIS AND CARNITINE INSUFFICIENCY [J].

TRIGGS, WJ ;

BOHAN, TP ;

LIN, SN ;

WILLMORE, LJ .

ARCHIVES OF NEUROLOGY, 1990, 47 (10) :1131-1133

[16] PLASMA CARNITINE CONCENTRATIONS IN CARDIOMYOPATHY PATIENTS [J].

TRIPP, ME ;

SHUG, AL .

BIOCHEMICAL MEDICINE, 1984, 32 (02) :199-206

[17] CARNITINE DEFICIENCY PRESENTING AS FAMILIAL CARDIOMYOPATHY - A TREATABLE DEFECT IN CARNITINE TRANSPORT [J].

WABER, LJ ;

VALLE, D ;

NEILL, C ;

DIMAURO, S ;

SHUG, A .

JOURNAL OF PEDIATRICS, 1982, 101 (05) :700-705

[18] PLASMA CARNITINE DEFICIENCY - CLINICAL OBSERVATIONS IN 51 PEDIATRIC-PATIENTS [J].

WINTER, SC ;

SZABOACZEL, S ;

CURRY, CJR ;

HUTCHINSON, HT ;

HOGUE, R ;

SHUG, A .

AMERICAN JOURNAL OF DISEASES OF CHILDREN, 1987, 141 (06) :660-665

[19] FATAL REYE-LIKE SYNDROME ASSOCIATED WITH VALPROIC ACID [J].

YOUNG, RSK ;

BERGMAN, I ;

GANG, DL ;

RICHARDSON, EP .

ANNALS OF NEUROLOGY, 1980, 7 (04) :389-389

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